Age-dependent changes of airway and lung parenchyma in C57BL/6J mice.

Age-dependent changes of airway and lung parenchyma in C57BL/6J mice. Research Abstract Details 

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Age-dependent changes of airway and lung parenchyma in C57BL/6J mice. Abstract Text:

Kewu Huang,Richard Rabold,Brian Schofield,Wayne Mitzner,Clarke G Tankersley,

In the current study, we hypothesize that senescent-dependent changes between airway and lung parenchymal tissues of C57BL/6J (B6) mice are not synchronized with respect to altered lung mechanics. Furthermore, aging modifications in elastin fiber and collagen content of the airways and lung parenchyma are remodeling events that differ with time. To test these hypotheses, we performed quasi-static pressure-volume (PV) curves and impedance measurements of the respiratory system in 2-, 20-, and 26-mo-old B6 mice. From the PV curves, the lung volume at 30 cmH(2)O pressure (V(30)) and respiratory system compliance (Crs) were significantly (P < 0.01) increased between 2 and 20 mo of age, representing about 80-84% of the total increase that occurred between 2 and 26 mo of age. Senescent-dependent changes in tissue damping and tissue elastance were analogous to changes in V(30) and Crs; that is, a majority of the parenchymal alterations in the lung mechanics occurred between 2 and 20 mo of age. In contrast, significant decreases in airway resistance (R) occurred between 20 and 26 mo of age; that is, the decrease in R between 2 and 20 mo of age represented only 29% (P > 0.05) of total decrease occurring through 26 mo. Morphometric analysis of the elastic fiber content in lung parenchyma was significantly (P < 0.01) decreased between 2 and 20 mo of age. To the contrary, increased collagen content was significantly delayed until 26 mo of age (P < 0.01, 2 vs. 26 mo). In conclusion, our data demonstrate that senescent-dependent changes in airway and lung tissue mechanics are not synchronized in B6 mice. Moreover, the reduction in elastic fiber content with age is an early lung remodeling event, and the increased collagen content in the lung parenchyma occurs later in senescence.

Age-dependent changes of airway and lung parenchyma in C57BL/6J mice. Publishing Authors By Initials

K Huang,R Rabold,B Schofield,W Mitzner,CG Tankersley,

For similar respiratory system research abstracts see: respiratory system research

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Age-dependent changes of airway and lung parenchyma in C57BL/6J mice. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of applied physiology (Bethesda, Md. : 198

VOLUME: 102

Page Numbers: 200-6

Journal Abbreviation: J. Appl. Physiol.

ISSN: 8750-7587

DAY: 31

MONTH: 08

YEAR: 2006

Age-dependent changes of airway and lung parenchyma in C57BL/6J mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8502536

Age-dependent changes of airway and lung parenchyma in C57BL/6J mice. Keywords Mesh Terms:

KEYWORDS: Respiratory System

MESH TERMS: pathology

Chemical & Substance for Abstract: Age-dependent changes of airway and lung parenchyma in C57BL/6J mice. Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for Age-dependent changes of airway and lung parenchyma in C57BL/6J mice.

AFFILIATION: Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences, Baltimore, Maryland, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL-010342

ACRONYM: HL

MEDLINETA: J Appl Physiol

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