Age dependency of mitochondrial DNA decrease differs in different tissues of rat.

Age dependency of mitochondrial DNA decrease differs in different tissues of rat. Research Abstract Details 

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Age dependency of mitochondrial DNA decrease differs in different tissues of rat. Abstract Text:

K Asano,M Nakamura,T Sato,H Tauchi,A Asano,

Mitochondrial DNA contents were measured using non-radioactive DNA probes for specific mtDNA sequences. The nuclear repetitive DNA sequence, LINE, was used as an internal standard marker. Age-dependent decreases in the mtDNA/nucDNA ratio in rat hepatic cells were confirmed with this method and, furthermore, a similar decrease was found in cardiac muscles. On the other hand, in thigh skeletal muscles such a decrease was not observed, slight increases being rather found in 18- to 24-month-old rats. The possible relationship of the decrease in mtDNA and the mechanism underlying animal senescence was discussed.

Age dependency of mitochondrial DNA decrease differs in different tissues of rat. Publishing Authors By Initials

K Asano,M Nakamura,T Sato,H Tauchi,A Asano,

For similar animals: animal population groups: animals, inbred strains: rats, inbred strains research abstracts see: animals: animal population groups: animals, inbred strains: rats, inbred strains research

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Age dependency of mitochondrial DNA decrease differs in different tissues of rat. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 114

Page Numbers: 303-6

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Sep

YEAR: 1993

Age dependency of mitochondrial DNA decrease differs in different tissues of rat. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Age dependency of mitochondrial DNA decrease differs in different tissues of rat. Keywords Mesh Terms:

KEYWORDS: Rats, Inbred Strains

MESH TERMS: physiology

Chemical & Substance for Abstract: Age dependency of mitochondrial DNA decrease differs in different tissues of rat. Information

Substance Name: Genetic Markers

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Grant and Affiliation Information for Age dependency of mitochondrial DNA decrease differs in different tissues of rat.

AFFILIATION: College of Medical Technology, Kyoto University.

Country: JAPAN

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MEDLINETA: J Biochem

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