[Affect of As(2)O(3) on the sister chromatid exchanges in human blood lymphocytes]

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[Affect of As(2)O(3) on the sister chromatid exchanges in human blood lymphocytes] Abstract Text:

L Chen,Y Liang,S Jiang,

OBJECTIVE: To assess the potential of As(2)O(3) in inducing malignant transformation at its therapeutic concentrations. METHODS: The sister chromatid exchange (SCE) in human peripheral blood lymphocytes (PBL) treated with different concentrations of As(2)O(3) was detected by the staining technique for sister chromatid differentiation. RESULTS: At 2 x 10(-6)mol/L and 1 x 10(-6) mol/L of As(2)O(3), the SCE frequency in PBLs was significantly increased as compared with the control (P < 0.01). Most of the lymphocytes were arrested at the first cell cycle (M1) and the mitotic index was significantly decreased in a dose dependent manner. At 1 x 10(-7) mol/L or less of As(2)O(3), the SCE frequency, the cell proliferation kinetics and the mitotic index in PBLs were similar to the control (P > 0.05). CONCLUSION: It seemed that As(2)O(3) might induce transformation and affect the function of lymphocytes when used within the therapeutical concentration range.

[Affect of As(2)O(3) on the sister chromatid exchanges in human blood lymphocytes] Publishing Authors By Initials

L Chen,Y Liang,S Jiang,

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[Affect of As(2)O(3) on the sister chromatid exchanges in human blood lymphocytes] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 22

Page Numbers: 363-5

Journal Abbreviation: Zhonghua Xue Ye Xue Za Zhi

ISSN: 0253-2727

DAY: 5

MONTH: Jul

YEAR: 2001

[Affect of As(2)O(3) on the sister chromatid exchanges in human blood lymphocytes] Information

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LANGUAGE: chi

NlmUniqueID: 8212398

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Grant and Affiliation Information for [Affect of As(2)O(3) on the sister chromatid exchanges in human blood lymphocytes]

AFFILIATION: Department of Hospital Administration, Yunnan Armed Police Hospital, Kunming 650111, China.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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