Aerosol-delivered programmed cell death 4 enhanced apoptosis, controlled cell cycle and suppressed AP-1 activity in the lungs of AP-1 luciferase reporter mice.

Aerosol-delivered programmed cell death 4 enhanced apoptosis, controlled cell cycle and suppressed AP-1 activity in the lungs of AP-1 luciferase reporter mice. Research Abstract Details 

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Aerosol-delivered programmed cell death 4 enhanced apoptosis, controlled cell cycle and suppressed AP-1 activity in the lungs of AP-1 luciferase reporter mice. Abstract Text:

S-K Hwang,H Jin,J T Kwon,S-H Chang,T H Kim,C-S Cho,K H Lee,M R Young,N H Colburn,G R Beck,H-S Yang,M-H Cho,S-K Hwang,H Jin,J T Kwon,S-H Chang,T H Kim,C-S Cho,K H Lee,M R Young,N H Colburn,G R Beck,H-S Yang,M-H Cho,

The long-term survival of lung cancer patients treated with conventional therapies remains poor and therefore the need for novel approaches remains high. This has led to the re-emergence of aerosol delivery as a therapeutic intervention. In this study, glucosylated polyethylenimine (GPEI) was used as carrier to investigate programmed cell death 4 (PDCD4) and PDCD4 mutant (D418A), an eIF4A-binding mutant, on PDCD4-related signaling and activator protein-1 (AP-1) activity in the lungs of AP-1 luciferase reporter mice. After confirming the efficiency of GPEI as a carrier in lungs, the effects of aerosol-delivered PDCD4 were investigated in AP-1 luciferase reporter mice. Aerosol delivery of GPEI/PDCD4 through a nose-only inhalation facilitated the apoptosis of lungs whereas aerosol PDCD4 mutant did not. Also, such aerosol delivery regulated proteins relevant to cell-cycle control and suppressed AP-1 activity. Results obtained by western blot analysis, immunohistochemistry, luciferase assay and deoxynucleotidyl-transferase-mediated nick end labeling study suggest that combined actions such as facilitating apoptosis, controlling cell cycle and suppression of AP-1 activity by PDCD4 may provide useful tool for designing lung tumor prevention and treatment by which PDCD4 functions as a transformation suppressor in the future.

Aerosol-delivered programmed cell death 4 enhanced apoptosis, controlled cell cycle and suppressed AP-1 activity in the lungs of AP-1 luciferase reporter mice. Publishing Authors By Initials

SK Hwang,H Jin,JT Kwon,SH Chang,TH Kim,CS Cho,KH Lee,MR Young,NH Colburn,GR Beck,HS Yang,MH Cho,SK Hwang,H Jin,JT Kwon,SH Chang,TH Kim,CS Cho,KH Lee,MR Young,NH Colburn,GR Beck,HS Yang,MH Cho,

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Aerosol-delivered programmed cell death 4 enhanced apoptosis, controlled cell cycle and suppressed AP-1 activity in the lungs of AP-1 luciferase reporter mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Gene therapy

VOLUME: 14

Page Numbers: 1353-61

Journal Abbreviation: Gene Ther.

ISSN: 0969-7128

DAY: 5

MONTH: 07

YEAR: 2007

Aerosol-delivered programmed cell death 4 enhanced apoptosis, controlled cell cycle and suppressed AP-1 activity in the lungs of AP-1 luciferase reporter mice. Information

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LANGUAGE: eng

NlmUniqueID: 9421525

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Grant and Affiliation Information for Aerosol-delivered programmed cell death 4 enhanced apoptosis, controlled cell cycle and suppressed AP-1 activity in the lungs of AP-1 luciferase reporter mice.

AFFILIATION: Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul, Korea.

Country: England

AGENCY: United States NCI

GRANT: CA84573

ACRONYM: CA

MEDLINETA: Gene Ther

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