Adverse ocular effects associated with niacin therapy.

Adverse ocular effects associated with niacin therapy. Research Abstract Details 

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Adverse ocular effects associated with niacin therapy. Abstract Text:

In a retrospective survey of patients taking medication for hyperlipidaemia, those taking niacin (nicotinic acid) were more likely (p < 0.05) to report sicca syndromes, blurred vision, eyelid oedema, and macular oedema compared with those who never took niacin. Additionally, 7% of those taking niacin discontinued the drug owing to adverse ocular side effects, while none of the other lipid lowering agents were found to cause these side effects (p = 0.016). Data from spontaneous reporting systems support a possible association of decreased vision, cystoid macular oedema, sicca-like symptoms, discoloration of the eyelids with or without periorbital or eyelid oedema, proptosis, loss of eyebrow or eyelashes, and superficial punctate keratitis with the use of niacin in high doses. Decreased vision may be marked, and if the drug is not discontinued, may progress to cystoid macular oedema. All ocular side effects listed above are reversible if the association with niacin is recognised and the drug is discontinued; both the incidence and severity of the ocular side effects seem to be dose dependent.

Adverse ocular effects associated with niacin therapy. Publishing Authors By Initials

For similar eye diseases: conjunctival diseases: xerophthalmia research abstracts see: eye diseases: conjunctival diseases: xerophthalmia research

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Adverse ocular effects associated with niacin therapy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The British journal of ophthalmology

VOLUME: 79

Page Numbers: 54-6

Journal Abbreviation: Br J Ophthalmol

ISSN: 0007-1161

DAY: 28

MONTH: Jan

YEAR: 1995

Adverse ocular effects associated with niacin therapy. Information

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LANGUAGE: eng

NlmUniqueID: 421041

Adverse ocular effects associated with niacin therapy. Keywords Mesh Terms:

KEYWORDS: Xerophthalmia

MESH TERMS: chemically induced

Chemical & Substance for Abstract: Adverse ocular effects associated with niacin therapy. Information

Substance Name: Niacin

Registry Number: 59-67-6

Grant and Affiliation Information for Adverse ocular effects associated with niacin therapy.

AFFILIATION: Oregon Health Sciences University, Department of Ophthalmology, Portland 97201.

Country: ENGLAND

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MEDLINETA: Br J Ophthalmol

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