Adverse effects of rabies pre- and postexposure prophylaxis in 290 health-care-workers exposed to a rabies infected organ donor or transplant recipients.

Adverse effects of rabies pre- and postexposure prophylaxis in 290 health-care-workers exposed to a rabies infected organ donor or transplant recipients. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Adverse effects of rabies pre- and postexposure prophylaxis in 290 health-care-workers exposed to a rabies infected organ donor or transplant recipients. Abstract Text:

F Mattner,F Bitz,M Goedecke,A Viertel,S Kuhn,P Gastmeier,L Mattner,F Biertz,A Heim,C Henke-Gendo,I Engelmann,A Martens,M ,T F Schulz,F Mattner,F Bitz,M Goedecke,A Viertel,S Kuhn,P Gastmeier,L Mattner,F Biertz,A Heim,C Henke-Gendo,I Engelmann,A Martens,M ,T F Schulz,

The recent unfortunate rabies transmissions through solid organ transplants of an infected donor in Germany required the initiation of a vaccination program to protect health care workers (HCWs) with close contact to rabies-infected patients. A systematic follow-up of adverse effects was initiated. Rabies postexposure prophylaxis (PEP) was started in 269 HCWs at four German hospitals. Pre-exposure prophylaxis (PreEP) was administered to 74 HCWs caring for an already diagnosed rabies patient. At each vaccination date, HCWs were interviewed for symptoms possibly representing adverse effects. Adverse effects of PEP and PrePEP were compared. Out of 269 HCWs, 216 were included for the investigation of adverse effects. Of these 216 HCWs, 114 (53%) individuals developed at least one systemic adverse effect. Incidences of tiredness (30.6%), malaise (26.4%), headache (26.9%), dizziness (14.8%), and chills (13.0%) declined in the course of PEP (p < 0.05), whereas incidences of fever (7.4%), paraesthesias (7.9%), arthralgias (1.9%), myalgias (4.2%), nausea (9.3%), diarrheas (2.8%) and vomiting (1.4%) did not. In 11 (5.1%) HCWs PEP was discontinued mostly due to adverse reactions (four suffered strong headaches, two HCWs meningeal irritations, two chills, one paraesthesia, one malaise, and one a rush). Systemic effects of PEP or PreEP did not differ significantly. Despite relatively high incidences of moderate severe adverse reactions rabies PEP is safe. Strong headache, tiredness, dizziness, and paraesthesias are the most important postvaccinal symptoms. Vaccinees suffering from adverse effects of PEP must be strongly encouraged to complete PEP, as it is to date the only protection against fatal rabies.

Adverse effects of rabies pre- and postexposure prophylaxis in 290 health-care-workers exposed to a rabies infected organ donor or transplant recipients. Publishing Authors By Initials

F Mattner,F Bitz,M Goedecke,A Viertel,S Kuhn,P Gastmeier,L Mattner,F Biertz,A Heim,C Henke-Gendo,I Engelmann,A Martens,M ,TF Schulz,F Mattner,F Bitz,M Goedecke,A Viertel,S Kuhn,P Gastmeier,L Mattner,F Biertz,A Heim,C Henke-Gendo,I Engelmann,A Martens,M ,TF Schulz,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Adverse effects of rabies pre- and postexposure prophylaxis in 290 health-care-workers exposed to a rabies infected organ donor or transplant recipients. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Infection

VOLUME: 35

Page Numbers: 219-24

Journal Abbreviation: Infection

ISSN: 0300-8126

DAY: 23

MONTH: 07

YEAR: 2007

Adverse effects of rabies pre- and postexposure prophylaxis in 290 health-care-workers exposed to a rabies infected organ donor or transplant recipients. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 365307

Adverse effects of rabies pre- and postexposure prophylaxis in 290 health-care-workers exposed to a rabies infected organ donor or transplant recipients. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Adverse effects of rabies pre- and postexposure prophylaxis in 290 health-care-workers exposed to a rabies infected organ donor or transplant recipients. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Adverse effects of rabies pre- and postexposure prophylaxis in 290 health-care-workers exposed to a rabies infected organ donor or transplant recipients.

AFFILIATION: Institute of Medical Microbiology and Hygiene, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.

Country: Germany

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Infection

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Adverse effects of rabies pre- and postexposure prophylaxis in 290 health-care-workers exposed to a rabies infected organ donor or transplant recipients Related Publications

• Acute actions and novel targets of matrix metalloproteinases in the heart and vasculature.
• Adverse effects of rabies pre- and postexposure prophylaxis in 290 health-care-workers exposed to a rabies infected organ donor or transplant recipients.
• Antagonistic roles of Rac and Rho in organizing the germ cell microenvironment.
• Antioxidant mechanism is involved in the gastroprotective effects of ozonized sunflower oil in ethanol-induced ulcers in rats.
• Approach for reconstructing anisoplanatic adaptive optics images.
• Caregiver intervention research: an opportunity for collaboration between caregiving investigators and African-american faith communities.
• Caregiving at the end of life.
• Depression and distress predict time to cardiovascular disease in dementia caregivers.
• Depressive symptoms in older African-American and white adults with functional difficulties: the role of control strategies.
• Does who you marry matter for your health? Influence of patients' and spouses' personality on their partners' psychological well-being following coronary artery bypass surgery.
• Energy profile of maltooligosaccharide permeation through maltoporin as derived from the structure and from a statistical analysis of saccharide-protein interactions.
• Heart development in Drosophila.
• High resolution structure and catalysis of O-acetylserine sulfhydrylase isozyme B from Escherichia coli.
• Identification of a crystal cell-specific enhancer of the black cells prophenoloxidase gene in Drosophila.
• Inflammatory response to TiO2 and carbonaceous particles scales best with BET surface area.
• L1 retrotransposons in human cancers.
• Magnetic resonance imaging of the clavicular ossification.
• Matrix metalloproteinase-2 degrades the cytoskeletal protein alpha-actinin in peroxynitrite mediated myocardial injury.
• Religion, spirituality and the well-being of informal caregivers: a review, critique, and research prospectus.
• Religious beliefs and practices are associated with better mental health in family caregivers of patients with dementia: findings from the REACH study.
• Requirement of the LIM homeodomain transcription factor tailup for normal heart and hematopoietic organ formation in Drosophila melanogaster.
• Solid lipid templating of macroporous tissue engineering scaffolds.
• Structure and action of the N-oxygenase AurF from Streptomyces thioluteus.
• Structure and reaction geometry of geranylgeranyl diphosphate synthase from Sinapis alba.
• Structure of maltoporin from Salmonella typhimurium ligated with a nitrophenyl-maltotrioside.
• The cell surface glycosphingolipids SSEA-3 and SSEA-4 are not essential for human ESC pluripotency.
• U-shaped protein domains required for repression of cardiac gene expression in Drosophila.
• [An extreme case of undoing and posing in a case of murder-suicide. A forensic pathological approach to crime scene investigation]
• [Carpo-metacarpal flexion of the thumb in healthy adults]
• [Immunohistochemical proof of amelogenin in teeth--a contribution to the evaluation of the age in the identification of unknown corpses]