Adverse central nervous system effects of older antihistamines in children.

Adverse central nervous system effects of older antihistamines in children. Research Abstract Details 

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Adverse central nervous system effects of older antihistamines in children. Abstract Text:

Although older, potentially sedating, "first-generation" antihistamines (H1-receptor antagonists) are commonly used in childhood, their central nervous system (CNS) effects have not been well-documented in young subjects. We hypothesized that diphenhydramine and hydroxyzine would affect CNS function adversely in this population. Our objective was to evaluate the effects of these medications on central and peripheral histamine H1-receptors in children. Fifteen subjects with allergic rhinitis were tested before and 2-2.5 h after administration of diphenhydramine, hydroxyzine, or placebo in a double-blind, single-dose, three-way crossover study. Impairment of cognitive processing was assessed objectively by the latency of the P300 event-related potential (P300). Somnolence was assessed subjectively by a visual analog scale. Peripheral H1-blockade was assessed by suppression of the histamine-induced wheals and flares. At the central (Cz) and frontal (Fz) electrodes, diphenhydramine and hydroxyzine increased the P300 latency significantly (P < 0.05) compared to baseline. Hydroxyzine increased somnolence, as recorded on the visual analog scale, significantly compared to baseline (P < 0.05), with a similar trend for diphenhydramine (P = 0.07). Both antihistamines reduced histamine-induced wheals and flares significantly compared to baseline and compared to placebo. In children, diphenhydramine and hydroxyzine are effective H1-receptor antagonists, but both these medications cause CNS dysfunction, as evidenced by increased P300 latency, a measure of cognitive function, and by increased subjective somnolence.

Adverse central nervous system effects of older antihistamines in children. Publishing Authors By Initials

For similar diagnosis: diagnostic techniques and procedures: skin tests research abstracts see: diagnosis: diagnostic techniques and procedures: skin tests research

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Adverse central nervous system effects of older antihistamines in children. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pediatric allergy and immunology : official public

VOLUME: 7

Page Numbers: 22-7

Journal Abbreviation: Pediatr Allergy Immunol

ISSN: 0905-6157

DAY: 28

MONTH: Feb

YEAR: 1996

Adverse central nervous system effects of older antihistamines in children. Information

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LANGUAGE: eng

NlmUniqueID: 9106718

Adverse central nervous system effects of older antihistamines in children. Keywords Mesh Terms:

KEYWORDS: Skin Tests

MESH TERMS: drug effects

Chemical & Substance for Abstract: Adverse central nervous system effects of older antihistamines in children. Information

Substance Name: Hydroxyzine

Registry Number: 68-88-2

Grant and Affiliation Information for Adverse central nervous system effects of older antihistamines in children.

AFFILIATION: Faculty of Medicine, University of Manitoba, Winnipeg, Canada.

Country: DENMARK

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MEDLINETA: Pediatr Allergy Immunol

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