Adverse biochemical and physiological effects of prostacyclin in experimental brain oedema.

Adverse biochemical and physiological effects of prostacyclin in experimental brain oedema. Research Abstract Details 

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Adverse biochemical and physiological effects of prostacyclin in experimental brain oedema. Abstract Text:

BACKGROUND: Prostacyclin (PGI2) and its stable analogues are known to reduce capillary hydraulic permeability. This study explores the biochemical and physiological effects of i.v. infusion of low-dose PGI2 in an experimental model of vasogenic brain oedema. METHODS: Twenty-seven anaesthetized and mechanically ventilated piglets with brain oedema induced by intrathecal injection of lipopolysaccharide (LPS) were used. Five of the animals received a continuous infusion of PGI2 (1 ng kg(-1) min(-1)) i.v. Four microdialysis catheters were placed in the brain to measure interstitial concentrations of glucose, lactate, and glycerol. Mean arterial pressure (MAP), intracranial pressure (ICP) and temperature were monitored continuously. Low-dose infusion of PGI2 started 1 h before the LPS injection and was constant during the study period. RESULTS: Intracranial pressure increased significantly in animals treated with PGI2. The increase in ICP was associated with significant cerebral biochemical changes: decrease in glucose, increase in lactate, increase in lactate/glucose ratio and increase in glycerol. CONCLUSION: In LPS-induced brain oedema i.v. infusion of low-dose PGI2 caused a further increase in ICP and a perturbation of energy metabolism, indicating cerebral ischemia and degradation of cellular membranes.

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Adverse biochemical and physiological effects of prostacyclin in experimental brain oedema. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta anaesthesiologica Scandinavica

VOLUME: 48

Page Numbers: 1316-21

Journal Abbreviation:

ISSN: 0001-5172

DAY: 20

MONTH: Nov

YEAR: 2004

Adverse biochemical and physiological effects of prostacyclin in experimental brain oedema. Information

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LANGUAGE: eng

NlmUniqueID: 370270

Adverse biochemical and physiological effects of prostacyclin in experimental brain oedema. Keywords Mesh Terms:

KEYWORDS: Swine

MESH TERMS: toxicity

Chemical & Substance for Abstract: Adverse biochemical and physiological effects of prostacyclin in experimental brain oedema. Information

Substance Name: Epoprostenol

Registry Number: 35121-78-9

Grant and Affiliation Information for Adverse biochemical and physiological effects of prostacyclin in experimental brain oedema.

AFFILIATION: Department of Anaesthesiology, Malmö University Hospital, Malmö, Sweden.

Country: Denmark

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MEDLINETA: Acta Anaesthesiol Scand

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