Advances in strategies to improve drug delivery to brain tumors.

Advances in strategies to improve drug delivery to brain tumors. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Advances in strategies to improve drug delivery to brain tumors. Abstract Text:

Herbert B Newton,

Brain tumors remain a significant health problem. Advances in the biology of the blood-brain barrier are improving the ability of researchers to target therapeutic peptides, small molecules and other drugs to brain tumors. Simple methods to improve blood-brain barrier penetration include chemical modification, glycosylation and pegylation. Drug-delivery vehicles, such as nanoparticles and liposomes, are also under study. Targeting vectors include natural ligands (e.g., epidermal growth factor) or monoclonal antibodies to receptors (e.g., transferrin or insulin). Other vector-mediated delivery approaches involve the conjugation of a therapeutic peptide or protein with a targeting molecule that can induce transcytosis across blood-brain barrier endothelial cells. The most commonly used vectors are peptidomimetic antibodies to endothelial receptors, such as the transferrin and insulin receptors.

Advances in strategies to improve drug delivery to brain tumors. Publishing Authors By Initials

HB Newton,

For similar animals: chordata: vertebrates: mammals: primates: haplorhini: catarrhini: hominidae: humans research abstracts see: animals: chordata: vertebrates: mammals: primates: haplorhini: catarrhini: hominidae: humans research

PUBMED ID PMID:

MEDLINE DATE:

Advances in strategies to improve drug delivery to brain tumors. Journal Published:

PUBLICATION TYPE: Review

Journal: Expert review of neurotherapeutics

VOLUME: 6

Page Numbers: 1495-509

Journal Abbreviation:

ISSN: 1744-8360

DAY: 3

MONTH: Oct

YEAR: 2006

Advances in strategies to improve drug delivery to brain tumors. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101129944

Advances in strategies to improve drug delivery to brain tumors. Keywords Mesh Terms:

KEYWORDS: Humans

MESH TERMS: trends

Chemical & Substance for Abstract: Advances in strategies to improve drug delivery to brain tumors. Information

Substance Name: Drug Carriers

Registry Number: 0

Grant and Affiliation Information for Advances in strategies to improve drug delivery to brain tumors.

AFFILIATION: Dardinger Neuro-oncology Center, Division of Neuro-oncology, 465 Means Hall, 1654 Upham Drive, Columbus, OH 43210, USA. newton.12@osu.edu

Country: England

AGENCY: United States NCI

GRANT: CA 16058

ACRONYM: CA

MEDLINETA: Expert Rev Neurother

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Advances in strategies to improve drug delivery to brain tumors Related Publications

• Advances in strategies to improve drug delivery to brain tumors.
• Amplitude Control of Protein Kinase C by RINCK, a Novel E3 Ubiquitin Ligase.
• Anterior and thoracoscopic scoliosis surgery for idiopathic scoliosis.
• Combined molecular and clinical assessment of Plasmodium falciparum antimalarial drug resistance in the Lao People's Democratic Republic (Laos).
• Comparisons among two fertile and three male-sterile mitochondrial genomes of maize.
• Conformations generated during turnover of the Azotobacter vinelandii nitrogenase MoFe protein and their relationship to physiological function.
• Electrophile-directed diastereoselective alkylation of prochiral enediolates.
• Epigenetic marking and neuronal plasticity.
• Explaining inappropriate strategy selection in a simple reasoning task.
• Further thoughts on the eradication of strangles in equids.
• GOTYS - Getting Older, Thinking Younger.
• How gaming is used as an innovative strategy for nursing education.
• Hydroxyurea chemotherapy in the treatment of meningiomas.
• Layer guided-acoustic plate mode biosensors for monitoring MHC-peptide interactions.
• Leveraging latent information in NMR spectra for robust predictive models.
• MDMA use and neurocognition: a meta-analytic review.
• Mechanisms of solute transport through outer membrane porins: burning down the house.
• Oral health acculturation in Albanian-speakers in south London.
• Oxygen depletion in relation to water residence times.
• Pathological gamblers demonstrate frontal lobe impairment consistent with that of methamphetamine-dependent individuals.
• Potentiation of NF-kappaB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells.
• Prospective study to determine accuracy of rapid serological assays for diagnosis of acute dengue virus infection in laos.
• Proteomic analysis identifies oxidative stress induction by adaphostin.
• Putting evidence into practice: does the workplace really matter?
• Risk factors for influenza infection in vaccinated racehorses: lessons from an outbreak in Newmarket, UK in 2003.
• Subjective and cardiovascular effects of cocaine during treatment with amantadine and baclofen in combination.
• The healing forearm fracture: a matched comparison of forearm refractures.
• The influence of personality on patients' satisfaction with existing and new complete dentures.
• The psychology of failure for dentists.
• The supercentenarians and how to get the most out of life.