Advances in chronic obstructive pulmonary disease.

Advances in chronic obstructive pulmonary disease. Research Abstract Details 

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Advances in chronic obstructive pulmonary disease. Abstract Text:

Peter J Barnes,

COPD is one of the commonest causes of morbidity and mortality in the world and is increasing in prevalence. Current therapies are not very effective and no current treatment prevents the relentless progression of airflow limitation that characterizes this disease. Smoking cessation is the only strategy that reduces this decline in lung function and, although bupropion is the most effective aid to quitting, more effective treatments of nicotine addition are needed. The mainstay of treatment is bronchodilators for symptom relief and inhaled anticholinergics and beta2-agonists are useful by reducing hyperinflation of the lungs. A new once daily inhaled anticholinergic is the most effective bronchodilator, but long-acting inhaled beta2-agonsts are also useful. Theophylline is used as an additional bronchodilator in more severe patients and may have some anti-inflammatory action. By contrast, inhaled corticosteroids are poorly effective and do not reduce disease profession, although recent studies with combination inhalers (corticosteroid + long-acting beta2-agonist) have shown better effects. Long-term oxygen therapy is needed by patients with pulmonary hypertension and right heart failure. There is a pressing need to develop new classes of therapy, and several new drugs are currently in development, including inteleukin-8 antagonists, phosphodiesterase-4 inhibitors, protease inhibitors and antioxidants.

Advances in chronic obstructive pulmonary disease. Publishing Authors By Initials

PJ Barnes,

For similar behavior and behavior mechanisms: behavior: tobacco use cessation: smoking cessation research abstracts see: behavior and behavior mechanisms: behavior: tobacco use cessation: smoking cessation research

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MEDLINE DATE:

Advances in chronic obstructive pulmonary disease. Journal Published:

PUBLICATION TYPE: Review

Journal: Transactions of the Medical Society of London

VOLUME: 119

Page Numbers: 41-51

Journal Abbreviation:

ISSN: 0076-6011

DAY: 19

MONTH: 11

YEAR: 2007

Advances in chronic obstructive pulmonary disease. Information

Number of References: 64

LANGUAGE: eng

NlmUniqueID: 7506118

Advances in chronic obstructive pulmonary disease. Keywords Mesh Terms:

KEYWORDS: Smoking Cessation

MESH TERMS: adverse effects

Chemical & Substance for Abstract: Advances in chronic obstructive pulmonary disease. Information

Substance Name: Glucocorticoids

Registry Number: 0

Grant and Affiliation Information for Advances in chronic obstructive pulmonary disease.

AFFILIATION: Thoracic Medicine, the National Heart and Lung Institute.

Country: England

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MEDLINETA: Trans Med Soc Lond

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