Adult vascular progenitor cells and tissue regeneration in metabolic syndrome.

Adult vascular progenitor cells and tissue regeneration in metabolic syndrome. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Adult vascular progenitor cells and tissue regeneration in metabolic syndrome. Abstract Text:

P M Humpert,H Eichler,A Lammert,H P Hammes,P P Nawroth,A Bierhaus,

Adult vascular progenitor cells (for example endothelial progenitor cells, EPC) have been studied for their contribution to vascular repair and angiogenesis. These cells can differentiate from bone marrow cells as well as circulating cells carrying hematopoetic stem cell markers. In vivo, they take part in vasculogenesis in different animal models of limb ischemia, myocardial infarction and wound healing. In metabolic disease, the outgrowth and function of EPC in vitro is defective and numbers of EPC correlate with classical risk factors of cardiovascular disease suggesting a role of EPC in the development of vascular complications. Pilot studies for the treatment of myocardial infarction and limb ischemia with autologous bone marrow showed a distinct therapeutic benefit that is presumably mediated by vasculogenesis in damaged tissues. However, little is known about the nature of EPC and their capability to differentiate into functional cells for tissue regeneration. In this article, we review and discuss the hitherto identified physiological function of EPC, the mechanisms leading to dysfunction of these cells and potential therapeutic applications in patients with metabolic syndrome or diabetes mellitus and vascular complications.

Adult vascular progenitor cells and tissue regeneration in metabolic syndrome. Publishing Authors By Initials

PM Humpert,H Eichler,A Lammert,HP Hammes,PP Nawroth,A Bierhaus,

For similar cardiovascular diseases: vascular diseases research abstracts see: cardiovascular diseases: vascular diseases research

PUBMED ID PMID:

MEDLINE DATE:

Adult vascular progenitor cells and tissue regeneration in metabolic syndrome. Journal Published:

PUBLICATION TYPE: Review

Journal: VASA. Zeitschrift für Gefässkrankheiten. Journal f

VOLUME: 34

Page Numbers: 73-8, 80

Journal Abbreviation: VASA

ISSN: 0301-1526

DAY: 13

MONTH: May

YEAR: 2005

Adult vascular progenitor cells and tissue regeneration in metabolic syndrome. Information

Number of References: 82

LANGUAGE: eng

NlmUniqueID: 317051

Adult vascular progenitor cells and tissue regeneration in metabolic syndrome. Keywords Mesh Terms:

KEYWORDS: Vascular Diseases

MESH TERMS: surgery

Chemical & Substance for Abstract: Adult vascular progenitor cells and tissue regeneration in metabolic syndrome. Information

Substance Name: Angiogenic Proteins

Registry Number: 0

Grant and Affiliation Information for Adult vascular progenitor cells and tissue regeneration in metabolic syndrome.

AFFILIATION: Universitätsklinikum Heidelberg, Abteilung Innere Medizin I, INF 410, Heidelberg, Germany.

Country: Switzerland

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Vasa

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Adult vascular progenitor cells and tissue regeneration in metabolic syndrome Related Publications

• Adult vascular progenitor cells and tissue regeneration in metabolic syndrome.
• High-mobility group box-1 in ischemia-reperfusion injury of the heart.
• Insulin stimulates the clonogenic potential of angiogenic endothelial progenitor cells by IGF-1 receptor-dependent signaling.
• The RAGE Pathway: Activation and Perpetuation in the Pathogenesis of Diabetic Neuropathy.
• [Not Available.]
• [Not Available.]
• sRAGE and esRAGE are not Associated with Peripheral or Autonomic Neuropathy in Type 2 Diabetes.