Adult spinal cord progenitor cells are repelled by netrin-1 in the embryonic and injured adult spinal cord.

Adult spinal cord progenitor cells are repelled by netrin-1 in the embryonic and injured adult spinal cord. Research Abstract Details 

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Adult spinal cord progenitor cells are repelled by netrin-1 in the embryonic and injured adult spinal cord. Abstract Text:

Audrey Petit,Drew L Sellers,Daniel J Liebl,Marc Tessier-Lavigne,Timothy E Kennedy,Philip J Horner,Audrey Petit,Drew L Sellers,Daniel J Liebl,Marc Tessier-Lavigne,Timothy E Kennedy,Philip J Horner,

Adult neural progenitor cells (aNPCs) exhibit limited migration in vivo with the exception of the rostral migratory stream and injury-induced movement. Surprisingly little is known regarding those signals regulating attraction or inhibition of the aNPC. These studies demonstrate that aNPCs respond principally to a repulsive cue expressed at the embryonic floor plate (FP) and also the injured adult CNS. Adult spinal cord progenitor cells (aSCPs) were seeded onto organotypic slice preparations of the intact embryonic or injured adult spinal cord. Cell migration assays combined with genetic and molecular perturbation of FP-derived migration cues or aSCP receptors establish netrin-1 (Ntn-1) but not Slit-2, Shh, or Ephrin-B3 as the primary FP-derived repellant. When slices were prepared from injured spinal cord, aSCP migration away from the injury core was Ntn-1-dependent. These studies establish Ntn-1 as a critical regulator of aSCP migration in the intact and injured CNS.

Adult spinal cord progenitor cells are repelled by netrin-1 in the embryonic and injured adult spinal cord. Publishing Authors By Initials

A Petit,DL Sellers,DJ Liebl,M Tessier-Lavigne,TE Kennedy,PJ Horner,A Petit,DL Sellers,DJ Liebl,M Tessier-Lavigne,TE Kennedy,PJ Horner,

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Adult spinal cord progenitor cells are repelled by netrin-1 in the embryonic and injured adult spinal cord. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 17837-42

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 31

MONTH: 10

YEAR: 2007

Adult spinal cord progenitor cells are repelled by netrin-1 in the embryonic and injured adult spinal cord. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

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Grant and Affiliation Information for Adult spinal cord progenitor cells are repelled by netrin-1 in the embryonic and injured adult spinal cord.

AFFILIATION: Department of Neurosurgery, University of Washington, Seattle, WA 98195, USA.

Country: United States

AGENCY: United States PHS

GRANT: R01 N546724

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MEDLINETA: Proc Natl Acad Sci U S A

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