Adult neurogenesis and cell cycle regulation in the crustacean olfactory pathway: from glial precursors to differentiated neurons.

Adult neurogenesis and cell cycle regulation in the crustacean olfactory pathway: from glial precursors to differentiated neurons. Research Abstract Details 

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Adult neurogenesis and cell cycle regulation in the crustacean olfactory pathway: from glial precursors to differentiated neurons. Abstract Text:

Jeremy M Sullivan,David C Sandeman,Jeanne L Benton,Barbara S Beltz,Jeremy M Sullivan,David C Sandeman,Jeanne L Benton,Barbara S Beltz,

Adult neurogenesis is a characteristic feature of the olfactory pathways of decapod crustaceans. In crayfish and clawed lobsters, adult-born neurons are the progeny of precursor cells with glial characteristics located in a neurogenic niche on the ventral surface of the brain. The daughters of these precursor cells migrate during S and G(2 )stages of the cell cycle along glial fibers to lateral (cluster 10) and medial (cluster 9) proliferation zones. Here, they divide (M phase) producing offspring that differentiate into olfactory interneurons. The complete lineage of cells producing neurons in these animals, therefore, is arranged along the migratory stream according to cell cycle stage. We have exploited this model to examine the influence of environmental and endogenous factors on adult neurogenesis. We find that increased levels of serotonin upregulate neuronal production, as does maintaining animals in an enriched (versus deprived) environment or augmenting their diet with omega-3 fatty acids; increased levels of nitric oxide, on the other hand, decrease the rate of neurogenesis. The features of the neurogenic niche and migratory streams, and the fact that these continue to function in vitro, provide opportunities unavailable in other organisms to explore the sequence of cellular and molecular events leading to the production of new neurons in adult brains.

Adult neurogenesis and cell cycle regulation in the crustacean olfactory pathway: from glial precursors to differentiated neurons. Publishing Authors By Initials

JM Sullivan,DC Sandeman,JL Benton,BS Beltz,JM Sullivan,DC Sandeman,JL Benton,BS Beltz,

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Adult neurogenesis and cell cycle regulation in the crustacean olfactory pathway: from glial precursors to differentiated neurons. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of molecular histology

VOLUME: 38

Page Numbers: 527-42

Journal Abbreviation: J. Mol. Histol.

ISSN: 1567-2379

DAY: 10

MONTH: 07

YEAR: 2007

Adult neurogenesis and cell cycle regulation in the crustacean olfactory pathway: from glial precursors to differentiated neurons. Information

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LANGUAGE: eng

NlmUniqueID: 101193653

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AFFILIATION: Neuroscience Program, Wellesley College, Wellesley, MA, 02481, USA, bbeltz@wellesley.edu.

Country: Netherlands

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MEDLINETA: J Mol Histol

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