Adult and larval photoreceptors use different mechanisms to specify the same Rhodopsin fates.

Adult and larval photoreceptors use different mechanisms to specify the same Rhodopsin fates. Research Abstract Details 

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Adult and larval photoreceptors use different mechanisms to specify the same Rhodopsin fates. Abstract Text:

Simon G Sprecher,Franck Pichaud,Claude Desplan,

Although development of the adult Drosophila compound eye is very well understood, little is known about development of photoreceptors (PRs) in the simple larval eye. We show here that the larval eye is composed of 12 PRs, four of which express blue-sensitive rhodopsin5 (rh5) while the other eight contain green-sensitive rh6. This is similar to the 30:70 ratio of adult blue and green R8 cells. However, the stochastic choice of adult color PRs and the bistable loop of the warts and melted tumor suppressor genes that unambiguously specify rh5 and rh6 in R8 PRs are not involved in specification of larval PRs. Instead, primary PR precursors signal via EGFR to surrounding tissue to develop as secondary precursors, which will become Rh6-expressing PRs. EGFR signaling is required for the survival of the Rh6 subtype. Primary precursors give rise to the Rh5 subtype. Furthermore, the combinatorial action of the transcription factors Spalt, Seven-up, and Orthodenticle specifies the two PR subtypes. Therefore, even though the larval PRs and adult R8 PRs express the same rhodopsins (rh5 and rh6), they use very distinct mechanisms for their specification.

Adult and larval photoreceptors use different mechanisms to specify the same Rhodopsin fates. Publishing Authors By Initials

SG Sprecher,F Pichaud,C Desplan,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Adult and larval photoreceptors use different mechanisms to specify the same Rhodopsin fates. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Genes & development

VOLUME: 21

Page Numbers: 2182-95

Journal Abbreviation: Genes Dev.

ISSN: 0890-9369

DAY: 1

MONTH: Sep

YEAR: 2007

Adult and larval photoreceptors use different mechanisms to specify the same Rhodopsin fates. Information

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LANGUAGE: eng

NlmUniqueID: 8711660

Adult and larval photoreceptors use different mechanisms to specify the same Rhodopsin fates. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: physiology

Chemical & Substance for Abstract: Adult and larval photoreceptors use different mechanisms to specify the same Rhodopsin fates. Information

Substance Name: Protein Kinases

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Adult and larval photoreceptors use different mechanisms to specify the same Rhodopsin fates.

AFFILIATION: Center for Developmental Genetics, Department of Biology, New York University, New York, New York 10003, USA.

Country: United States

AGENCY: United States NEI

GRANT: EY013010

ACRONYM: EY

MEDLINETA: Genes Dev

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