Adrenergic receptors and sodium reabsorption in normotensive subjects as related to salt sensitivity.

Adrenergic receptors and sodium reabsorption in normotensive subjects as related to salt sensitivity. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Adrenergic receptors and sodium reabsorption in normotensive subjects as related to salt sensitivity. Abstract Text:

P Kotanko,F Skrabal,G Gruber,P Doll,B Meister,

We have studied proximal tubular sodium reabsorption as measured by lithium clearance, alpha-2 and beta-2 adrenergic receptors on circulating platelets and lymphocytes, respectively, and urinary aldosterone after variations of sodium intake in 24 normotensive volunteers. Fractional lithium clearance was 14.8% +/- 2.64 under a high salt diet of 200 mmol per day. After a low salt diet of 50 mmol/d for two weeks fractional lithium clearance did not change significantly (13.3% +/- 3.35). There were no correlations between alpha-2 adrenergic receptors, beta-2 adrenergic receptors or the alpha-2/beta-2 ratio and fractional lithium clearance, irrespective of the high or low salt diet. In contrast, a significant correlation was found between urinary aldosterone excretion and alpha-2 receptor densities under low salt diet (r = -0.55, n = 17, p less than 0.02). There were no correlations between beta-2 adrenoceptor density, alpha-2/beta-2 ratio and urinary aldosterone during high or low salt diet. Whereas our results are inconclusive about the value of lithium clearance determinations as a measure of proximal tubular sodium reabsorption during variations of sodium intake, we conclude, that alpha-adrenoceptor density, as measured on circulating blood cells, may possibly be representative for alpha-adrenergic equipment of the kidney. The inverse correlation between urinary aldosterone excretion in subjects equilibrated on a low salt diet of 50 mmol/d and alpha-2 adrenoceptor densities could be interpreted as an indirect evidence, that those subjects with a high alpha-2 adrenoceptor equipment show a high proximal tubular sodium reabsorption and thus can afford a low rate of aldosterone mediated distal tubular sodium reabsorption to maintain sodium balance. Our results are thus in accord with our previous hypothesis, that different receptor equipment of individual subjects may cause marked differences in sodium handling by the kidney. These differences may be responsible, at least in part, for the degree of salt sensitivity in individual subjects.

Adrenergic receptors and sodium reabsorption in normotensive subjects as related to salt sensitivity. Publishing Authors By Initials

P Kotanko,F Skrabal,G Gruber,P Doll,B Meister,

For similar chlorides: sodium chloride research abstracts see: chlorides: sodium chloride research

PUBMED ID PMID:

MEDLINE DATE:

Adrenergic receptors and sodium reabsorption in normotensive subjects as related to salt sensitivity. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical and experimental hypertension. Part A, Th

VOLUME: 9 Suppl 1

Page Numbers: 307-18

Journal Abbreviation:

ISSN: 0730-0077

DAY: 12

MONTH: 02

YEAR: 1987

Adrenergic receptors and sodium reabsorption in normotensive subjects as related to salt sensitivity. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8207790

Adrenergic receptors and sodium reabsorption in normotensive subjects as related to salt sensitivity. Keywords Mesh Terms:

KEYWORDS: Sodium Chloride

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Adrenergic receptors and sodium reabsorption in normotensive subjects as related to salt sensitivity. Information

Substance Name: Sodium Chloride

Registry Number: 7647-14-5

Grant and Affiliation Information for Adrenergic receptors and sodium reabsorption in normotensive subjects as related to salt sensitivity.

AFFILIATION: Department of Internal Medicine, University of Innsbruck, Austria.

Country: UNITED STATES

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Clin Exp Hypertens A

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Adrenergic receptors and sodium reabsorption in normotensive subjects as related to salt sensitivity Related Publications

• A neural computation for visual acuity in the presence of eye movements.
• Adrenergic receptors and sodium reabsorption in normotensive subjects as related to salt sensitivity.
• Applications of human reliability to the production process. AMRL-TR-67-88.
• Classification, grading, and staging of soft tissue sarcomas.
• Comparative study of figure-ground discrimination in preschool children and adults.
• Compensation of the bias caused by the wall filter on the mean Doppler frequency.
• Differences in Scapular Upward Rotation between Baseball Pitchers and Position Players: 2515: Board #62 June 2 8:00 AM - 9:30 AM.
• Differences in scapular upward rotation between baseball pitchers and position players.
• Enzymatic degradation of triacetic acid lactone determined by a spectrophotometric method.
• From program to policy: expanding the role of community coalitions.
• Identification of human microRNA targets from isolated argonaute protein complexes.
• Lactonase and C-acylase activity of hepatoma.
• Metabolism of 3,5-diketohexanoic acid and its delta-lactone by tissue homogenates.
• Neurotransmitters in key neurons of the hypothalamus that regulate feeding behavior and body weight.
• Participation: of phenylacetyl-adenylate in the enzymic synthesis of phenylacetylglutamine.
• Polycystic disease of the liver; report of two cases diagnosed by peritoneoscopy.
• Presence of pituitary adenylate cyclase-activating polypeptide (PACAP) defines a subpopulation of hypothalamic POMC neurons.
• Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.
• Retinal adaptation to object motion.
• Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity.
• Studies on d- and tau-alpha-keto-beta-methylvaleric acids.
• [Causes of suture aneurysms]
• [Echinococcosis today--dawn of effective drug therapy]
• [In Process Citation]
• [J-pouch--the Erlangen experience]
• [Not Available.]
• [Present possibilities of antibiotic therapy in chronic non-specific respiratory diseases (author's transl)]
• [Residual cancer or not residual cancer--that is the question]
• [Suggestions for allergological diagnostics in outpatients' departments for lung diseases and tuberculosis (author's transl)]
• miRNAs get an early start on translational silencing.