Adrenalectomy-induced granule cell degeneration in the hippocampus causes spatial memory deficits that are not reversed by chronic treatment with corticosterone or fluoxetine.

Adrenalectomy-induced granule cell degeneration in the hippocampus causes spatial memory deficits that are not reversed by chronic treatment with corticosterone or fluoxetine. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Adrenalectomy-induced granule cell degeneration in the hippocampus causes spatial memory deficits that are not reversed by chronic treatment with corticosterone or fluoxetine. Abstract Text:

Simon C Spanswick,Jonathan R Epp,Julian R Keith,Robert J Sutherland,

Long-term adrenalectomy (ADX) causes a nearly complete and selective loss of granule cells in the dentate gyrus (DG) of the hippocampus. Previously, learning and memory deficits have been observed following ADX-induced granule cell degeneration for tasks that require the hippocampus. Our objective here was to determine whether corticosterone (CORT) replacement and treatment with the neurogenic compound fluoxetine could reverse behavioral deficits after ADX. We trained ADX and control rats in a moving, hidden platform version of the Morris water task before chronic administration (6 weeks) of CORT and either fluoxetine or vehicle. After treatment, all rats were retested in the Morris water task. Brains were labeled for the endogenous neurogenic markers Ki67 and doublecortin. Here we provide evidence that neurogenesis persists at a normal rate in the hippocampus after long-term ADX. After 8 weeks of CORT and fluoxetine administration, ADX-fluoxetine rats did not differ significantly compared to ADX-vehicle rats receiving CORT or compared to control rats in the number of Ki67 or doublecortin labeled cells. ADX-fluoxetine rats also did not significantly differ from ADX-vehicle rats in regards to granule cell layer thickness. Our results indicate that long-term ADX is associated with impaired spatial ability in the Morris water task and that neither chronic treatment with CORT, nor with CORT and fluoxetine are capable of altering the Morris water task deficit.

Adrenalectomy-induced granule cell degeneration in the hippocampus causes spatial memory deficits that are not reversed by chronic treatment with corticosterone or fluoxetine. Publishing Authors By Initials

SC Spanswick,JR Epp,JR Keith,RJ Sutherland,

For similar psychological phenomena and processes: mental processes: perception: space perception research abstracts see: psychological phenomena and processes: mental processes: perception: space perception research

PUBMED ID PMID:

MEDLINE DATE:

Adrenalectomy-induced granule cell degeneration in the hippocampus causes spatial memory deficits that are not reversed by chronic treatment with corticosterone or fluoxetine. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Hippocampus

VOLUME: 17

Page Numbers: 137-46

Journal Abbreviation:

ISSN: 1050-9631

DAY: 3

MONTH: 12

YEAR: 2007

Adrenalectomy-induced granule cell degeneration in the hippocampus causes spatial memory deficits that are not reversed by chronic treatment with corticosterone or fluoxetine. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9108167

Adrenalectomy-induced granule cell degeneration in the hippocampus causes spatial memory deficits that are not reversed by chronic treatment with corticosterone or fluoxetine. Keywords Mesh Terms:

KEYWORDS: Space Perception

MESH TERMS: physiology

Chemical & Substance for Abstract: Adrenalectomy-induced granule cell degeneration in the hippocampus causes spatial memory deficits that are not reversed by chronic treatment with corticosterone or fluoxetine. Information

Substance Name: Fluoxetine

Registry Number: 54910-89-3

Grant and Affiliation Information for Adrenalectomy-induced granule cell degeneration in the hippocampus causes spatial memory deficits that are not reversed by chronic treatment with corticosterone or fluoxetine.

AFFILIATION: Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada.

Country: United States

AGENCY: United States NIMH

GRANT: MH061460

ACRONYM: MH

MEDLINETA: Hippocampus

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Adrenalectomy-induced granule cell degeneration in the hippocampus causes spatial memory deficits that are not reversed by chronic treatment with corticosterone or fluoxetine Related Publications

• "Gray murder": characteristics of elderly compared with nonelderly homicide victims in New York City.
• A simple and efficient alternative to implementing systematic random sampling in stereological designs without a motorized microscope stage.
• A tandem aza-claisen rearrangement and ring closing metathesis reaction for the synthesis of cyclic allylic trichloroacetamides.
• Adrenalectomy-induced granule cell degeneration in the hippocampus causes spatial memory deficits that are not reversed by chronic treatment with corticosterone or fluoxetine.
• Allergic diseases and the nose.
• An episode of carbon tetrachloride poisoning with renal complications.
• Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression.
• Complete or partial hippocampal damage produces equivalent retrograde amnesia for remote contextual fear memories.
• Designing national quality reforms: a framework for action.
• Evidence for episodic memory in a pavlovian conditioning procedure in rats.
• Fluoxetine and the dentate gyrus: memory, recovery of function, and electrophysiology.
• Hyperbaric oxygen therapy improves spatial learning and memory in a rat model of chronic traumatic brain injury.
• Investigating cardiac function using motion and deformation analysis in the setting of coronary artery disease.
• Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression.
• Molecular connexions between dementia and diabetes.
• New strategies for combating multidrug-resistant bacteria.
• Population-scale drivers of individual arrival times in migratory birds.
• Progestins reinitiate cell cycle progression in antiestrogen-arrested breast cancer cells through the B-isoform of progesterone receptor.
• Repair dependent radiation survival: a stochastic model with Euler gamma function solutions.
• Review of centrifugal liquid-liquid chromatography using aqueous two-phase solvent systems: its scale-up and prospects for the future production of high-value biologicals.
• Seasonal Carriage of pfcrt and pfmdr1 Alleles in Gambian Plasmodium falciparum Imply Reduced Fitness of Chloroquine-Resistant Parasites.
• Sham procedure versus usual care as the control in clinical trials of devices: which is better?
• Simultaneous nucleotide activation and synthesis of amino acid amides by a potentially prebiotic multi-component reaction.
• Split-dose exposures versus dual ion exposure in human cell neoplastic transformation.
• Stepped Care for Affective Disorders and Musculoskeletal Pain (SCAMP) study Design and practical implications of an intervention for comorbid pain and depression.
• Synthesis, characterisation and anti-protozoal activity of carbamate-derived polyazamacrocycles.
• The Flip-side of Cytoadherence: Immune Selection, Antigenic Variation and the var Genes of Plasmodium falciparum.
• The apoptosis modulator and tumour suppressor protein RBM5 is a phosphoprotein.
• The histology of the endometrium in functional uterine haemorrhage; analysis of 1,000 cases and review of the literature.
• Two-step potentially prebiotic synthesis of alpha-d-cytidine-5'-phosphate from d-glyceraldehyde-3-phosphate.