Adoptive transfer of dying cells causes bystander-induced apoptosis.

Adoptive transfer of dying cells causes bystander-induced apoptosis. Research Abstract Details 

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Adoptive transfer of dying cells causes bystander-induced apoptosis. Abstract Text:

Steven J Schwulst,Christopher G Davis,Craig M Coopersmith,Richard S Hotchkiss,

The anti-apoptotic Bcl-2 protein has the remarkable ability to prevent cell death from several noxious stimuli. Intriguingly, Bcl-2 overexpression in one cell type has been reported to protect against cell death in neighboring non-Bcl-2 overexpressing cell types. The mechanism of this "trans" protection has been speculated to be secondary to the release of a cytoprotective factor by Bcl-2 overexpressing cells. We employed a series of adoptive transfer experiments in which lymphocytes that overexpress Bcl-2 were administered to either wild type mice or mice lacking mature T and B cells (Rag-1-/-) to detect the presence or absence of the putative protective factor. We were unable to demonstrate "trans" protection. However, adoptive transfer of apoptotic or necrotic cells exacerbated the degree of apoptotic death in neighboring non-Bcl-2 overexpressing cells (p < or= 0.05). Therefore, this data suggests that dying cells emit signals triggering cell death in neighboring non-Bcl-2 overexpressing cells, i.e., a "trans" destructive effect.

Adoptive transfer of dying cells causes bystander-induced apoptosis. Publishing Authors By Initials

SJ Schwulst,CG Davis,CM Coopersmith,RS Hotchkiss,

For similar tissues: lymphoid tissue: spleen research abstracts see: tissues: lymphoid tissue: spleen research

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Adoptive transfer of dying cells causes bystander-induced apoptosis. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biochemical and biophysical research communication

VOLUME: 353

Page Numbers: 780-5

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 22

MONTH: 12

YEAR: 2006

Adoptive transfer of dying cells causes bystander-induced apoptosis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372516

Adoptive transfer of dying cells causes bystander-induced apoptosis. Keywords Mesh Terms:

KEYWORDS: Spleen

MESH TERMS: cytology

Chemical & Substance for Abstract: Adoptive transfer of dying cells causes bystander-induced apoptosis. Information

Substance Name: Proto-Oncogene Proteins c-bcl-2

Registry Number: 0

Grant and Affiliation Information for Adoptive transfer of dying cells causes bystander-induced apoptosis.

AFFILIATION: Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM66202

ACRONYM: GM

MEDLINETA: Biochem Biophys Res Commun

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