Administration of substance P during a primary immune response amplifies the secondary immune response via a long-lasting effect on CD8+ T lymphocytes.

Administration of substance P during a primary immune response amplifies the secondary immune response via a long-lasting effect on CD8+ T lymphocytes. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Administration of substance P during a primary immune response amplifies the secondary immune response via a long-lasting effect on CD8+ T lymphocytes. Abstract Text:

Yoshiki Ikeda,Hisato Takei,Chinami Matsumoto,Akihito Mase,Masahiro Yamamoto,Shuichi Takeda,Atsushi Ishige,Kenji Watanabe,Yoshiki Ikeda,Hisato Takei,Chinami Matsumoto,Akihito Mase,Masahiro Yamamoto,Shuichi Takeda,Atsushi Ishige,Kenji Watanabe,

Atopic dermatitis can be exacerbated or induced by scratching or psychological stress; both cause the release of substance P (SP) from sensory nerves. Therefore, SP may have an etiological role in mechanisms underlying AD. Here, we show that administration of SP during the primary immune response (PIR) imprinted long-lasting pro-inflammatory immunity, resulting in exacerbation of the secondary immune response (SIR) in the absence of further SP. Five days after sensitization with dinitrofluorobenzene (DNFB), challenge with DNFB together with SP ("SP-Group") resulted in an increased PIR (as evaluated by ear swelling and granulocyte infiltration) compared to DNFB only ("Control-Group"). On day 26, after inflammation completely subsided, a second challenge with DNFB only (without SP) caused an increased SIR in the "SP-Group" compared to controls. Pretreatment on day 5 with spantide, an SP receptor antagonist, prevented increased ear swelling in the "SP-Group" not only on day 5 (PIR) but also on day 26 (SIR). In contrast, spantide treatment on day 26 did not affect the SIR. Adoptive transfer experiments suggested that CD8(+) T cells were involved in mediating enhanced SIR in animals pretreated on day 5 with SP. The present study offers a novel experimental approach to an uninvestigated facet of the pro-inflammatory effect of SP, i.e., exacerbation of inflammation via a long-term and indirect influence on CD8(+) T lymphocytes.

Administration of substance P during a primary immune response amplifies the secondary immune response via a long-lasting effect on CD8+ T lymphocytes. Publishing Authors By Initials

Y Ikeda,H Takei,C Matsumoto,A Mase,M Yamamoto,S Takeda,A Ishige,K Watanabe,Y Ikeda,H Takei,C Matsumoto,A Mase,M Yamamoto,S Takeda,A Ishige,K Watanabe,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Administration of substance P during a primary immune response amplifies the secondary immune response via a long-lasting effect on CD8+ T lymphocytes. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Archives of dermatological research

VOLUME: 299

Page Numbers: 345-51

Journal Abbreviation: Arch. Dermatol. Res.

ISSN: 0340-3696

DAY: 21

MONTH: 07

YEAR: 2007

Administration of substance P during a primary immune response amplifies the secondary immune response via a long-lasting effect on CD8+ T lymphocytes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8000462

Administration of substance P during a primary immune response amplifies the secondary immune response via a long-lasting effect on CD8+ T lymphocytes. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Administration of substance P during a primary immune response amplifies the secondary immune response via a long-lasting effect on CD8+ T lymphocytes. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Administration of substance P during a primary immune response amplifies the secondary immune response via a long-lasting effect on CD8+ T lymphocytes.

AFFILIATION: Pharmacology Research Department, Central Research Laboratories, Tsumura & Co., Tsumura Research Institute, Yoshiwara 3586, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan.

Country: Germany

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Arch Dermatol Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Administration of substance P during a primary immune response amplifies the secondary immune response via a long-lasting effect on CD8+ T lymphocytes Related Publications

• Analysis of the CC chemokine receptor 5 delta32 polymorphism in a Brazilian population with cutaneous leishmaniasis.
• Behavioral Determination of Odor Preference is Coded by the Oscillation Frequency in a Collective Oscillating Network of a Terrestrial Mollusk.
• Cost-effectiveness of radiofrequency ablation and surgical therapy for small hepatocellular carcinoma of 3cm or less in diameter.
• Decreased renal expressions of heat shock protein-72 and -25 are associated with renal dysfunction in biliary cirrhotic rats.
• Design of a synchrotron radiation source at Tohoku University.
• Divergent activities of interferon-alpha subtypes against intracellular hepatitis C virus replication.
• Effect of the moderate exercise on performance in upper/lower limb during long term bed rest.
• Effects of aminoglutethimide phosphate on litter size and birth weight in superovulated rats.
• Efficacy of ecabet sodium enema on steroid resistant or steroid dependent ulcerative colitis.
• Efficient Gene Transfer into Differentiated Human Trophoblast Cells with Adenovirus Vector Containing RGD Motif in the Fiber Protein.
• Enhancement of cytoprotective ability and cell restoration in 70-kDa heat shock protein gene-transfected rat gastric mucosal cells.
• Epimorphin expression and stellate cell status in mouse liver injury.
• Establishment of a novel chondrocytic cell line N1511 derived from p53-null mice.
• Genipin prevents fulminant hepatic failure resulting in reduction of lethality through the suppression of TNF-alpha production.
• Heart rate turbulence slope reduction in imminent ventricular tachyarrhythmia and its implications.
• Hepatic gene expression in hepatocyte-specific Pten deficient mice showing steatohepatitis without ethanol challenge.
• High-performance EUV/soft X-ray ellipsometry system using multilayer mirrors.
• Hydrodynamics-based gene delivery of naked DNA encoding fetal liver kinase-1 gene effectively suppresses the growth of pre-existing tumors.
• Mucins and ocular surface disease.
• Optical design for a bending-magnet beamline based on a varied-line-spacing plane grating.
• Proline promoted synthesis of ring-fused homodimers: self-condensation of alpha,beta-unsaturated aldehydes.
• Pyocyanin isolated from a marine microbial population: synergistic production between two distinct bacterial species and mode of action.
• Root caries prevalence in a group of Brazilian adult dental patients.
• Scrotal imaging.
• Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents.
• Technical note: measurement of ferritin in bovine milk and its clinical significance.
• Transmission multilayer polarizers for use in the 55-90 eV region.
• Treatment for intercostal arterial aneurysm in neurofibromatosis type 1.
• Two cases requiring external reinforcement in perceptual learning.
• Well-differentiated adenocarcinoma mimicking complete-type intestinal metaplasia in the stomach.