Adjuvant effect of CpG-oligodeoxynucleotide in anti-fungal chemotherapy against fatal infection with Cryptococcus neoformans in mice.

Adjuvant effect of CpG-oligodeoxynucleotide in anti-fungal chemotherapy against fatal infection with Cryptococcus neoformans in mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Adjuvant effect of CpG-oligodeoxynucleotide in anti-fungal chemotherapy against fatal infection with Cryptococcus neoformans in mice. Abstract Text:

Takeshi Kinjo,Kazuya Miyagi,Kiwamu Nakamura,Futoshi Higa,Xiao Gang,Akiko Miyazato,Mitsuo Kaku,Jiro Fujita,Kazuyoshi Kawakami,Takeshi Kinjo,Kazuya Miyagi,Kiwamu Nakamura,Futoshi Higa,Xiao Gang,Akiko Miyazato,Mitsuo Kaku,Jiro Fujita,Kazuyoshi Kawakami,

Cryptococcal meningoencephalitis is a life-threatening infectious disease in immunocompromised patients. Unmethylated CpG-oligodeoxynucleotides (CpG-ODN) protects hosts in a mouse model. In the present study, we tested the adjuvant effect of CpG-ODN in anti-fungal chemotherapy. Administration of either fluconazole (FLCZ) or CpG-ODN was effective in extending survival, accelerating clearance of fungi and preventing disseminated infection. Combination of both agents provided more beneficial effect than either agent alone. Cytokine balance in the infected lungs was biased to Th1-type response by CpGODN, while FLCZ did not further promote. These results suggest that CpG-ODN is a promising adjuvant in chemotherapy against this infection.

Adjuvant effect of CpG-oligodeoxynucleotide in anti-fungal chemotherapy against fatal infection with Cryptococcus neoformans in mice. Publishing Authors By Initials

T Kinjo,K Miyagi,K Nakamura,F Higa,X Gang,A Miyazato,M Kaku,J Fujita,K Kawakami,T Kinjo,K Miyagi,K Nakamura,F Higa,X Gang,A Miyazato,M Kaku,J Fujita,K Kawakami,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Adjuvant effect of CpG-oligodeoxynucleotide in anti-fungal chemotherapy against fatal infection with Cryptococcus neoformans in mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Microbiology and immunology

VOLUME: 51

Page Numbers: 741-6

Journal Abbreviation: Microbiol. Immunol.

ISSN: 0385-5600

DAY: 20

MONTH: 08

YEAR: 2007

Adjuvant effect of CpG-oligodeoxynucleotide in anti-fungal chemotherapy against fatal infection with Cryptococcus neoformans in mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7703966

Adjuvant effect of CpG-oligodeoxynucleotide in anti-fungal chemotherapy against fatal infection with Cryptococcus neoformans in mice. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Adjuvant effect of CpG-oligodeoxynucleotide in anti-fungal chemotherapy against fatal infection with Cryptococcus neoformans in mice. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Adjuvant effect of CpG-oligodeoxynucleotide in anti-fungal chemotherapy against fatal infection with Cryptococcus neoformans in mice.

AFFILIATION: Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Okinawa 903-0215, Japan.

Country: Japan

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Microbiol Immunol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Adjuvant effect of CpG-oligodeoxynucleotide in anti-fungal chemotherapy against fatal infection with Cryptococcus neoformans in mice Related Publications

• Adjuvant effect of CpG-oligodeoxynucleotide in anti-fungal chemotherapy against fatal infection with Cryptococcus neoformans in mice.
• An improved mouse model of atopic dermatitis and suppression of skin lesions by an inhibitor of tec family kinases.
• Autoaggressive effector T cells in the course of experimental autoimmune encephalomyelitis visualized in the light of two-photon microscopy.
• Compact ellipsometer employing a static polarimeter module with arrayed polarizer and wave-plate elements.
• Dectin-1 Is Not Required for the Host Defense to Cryptococcus neoformans.
• Defective interaction between dual oscillators for respiratory rhythm generation in Na+,K+-ATPase {alpha}2 subunit-deficient mice.
• Dysregulation of Src family kinases in mast cells from epilepsy-resistant ASK versus epilepsy-prone EL mice.
• Effect of diglucosamine on the entrapment of protein into liposomes.
• Elevation of the post-translational modification of proteins by O-linked N-acetylglucosamine leads to deterioration of the glucose-stimulated insulin secretion in the pancreas of diabetic Goto-Kakizaki rats.
• Fabrication of artificial endothelialized tubes with predetermined three-dimensional configuration from flexible cell-enclosing alginate fibers.
• Functional dissection of the Tol2 transposable element identified the minimal cis-sequence and a highly repetitive sequence in the subterminal region essential for transposition.
• Identification of a Novel Cancer-Testis Antigen CRT2 Frequently Expressed in Various Cancers Using Representational Differential Analysis.
• Identification of novel markers expressed during fin regeneration by microarray analysis in medaka fish.
• Immunohistochemical characteristics of bone forming cells in pleomorphic adenoma.
• In vivo behavior of muscle fascicles and tendinous tissues in human tibialis anterior muscle during twitch contraction.
• In vivo behavior of muscle fascicles and tendinous tissues of human gastrocnemius and soleus muscles during twitch contraction.
• Insertional mutagenesis by the Tol2 transposon-mediated enhancer trap approach generated mutations in two developmental genes: tcf7 and synembryn-like.
• Lens-free in-line optical isolators.
• Mid-term outcome of magnetic resonance-guided focused ultrasound surgery for uterine myomas: from six to twelve months after volume reduction.
• Notch signaling in mandibular condylar cartilage development.
• Photonic crystal waveguides utilizing a modulated lattice structure.
• Six1 is essential for early neurogenesis in the development of olfactory epithelium.
• Structure and infrared spectroscopy of group 6 transition-metal carbonyls in the gas phase: DFT studies on M(CO)n (M = Cr, Mo, and W; n = 6, 5, 4, and 3).
• Studies on experimental convulsions with emphasis on the role of the hypothalamus and the reticular formation.
• The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn.
• Tol2: a versatile gene transfer vector in vertebrates.
• Transposon-mediated gene trapping in zebrafish.
• Treatment for chronic abscess after cranioplasty: reconstruction of dura maters using the anterolateral thigh flap with fascia lata.
• [Comparison of regimen-related toxicity between high-dose melphalan and ICE as a preparatory regimen for autologous stem cell transplantation]
• [Comparison of salvage chemotherapy regimen ACES with ESHAP for refractory or relapsed malignant lymphoma]