Adiponectin, visceral fat, oxidative stress, and early macrovascular disease: the Coronary Artery Risk Development in Young Adults Study.

Adiponectin, visceral fat, oxidative stress, and early macrovascular disease: the Coronary Artery Risk Development in Young Adults Study. Research Abstract Details 

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Adiponectin, visceral fat, oxidative stress, and early macrovascular disease: the Coronary Artery Risk Development in Young Adults Study. Abstract Text:

Michael W Steffes,Myron D Gross,Duk-Hee Lee,Pamela J Schreiner,David R Jacobs,

OBJECTIVE: Adiponectin is a collagen-like product of visceral fat that offers apparent protection against macrovascular disease. We evaluated the relationships of concentrations of adiponectin with oxidative stress and the major risk factors for and/or the presence of macrovascular disease. RESEARCH METHODS AND PROCEDURES: Adiponectin was measured by radioimmunoassay in serum from 3045 fasting participants (ages 33 to 45) of the Coronary Artery Risk Development in Young Adults Study. Cross-sectional correlation of the concentrations of adiponectin with F2-isoprostane concentrations (a marker of systemic oxidative damage), coronary artery calcification (CAC; an estimate of early macrovascular disease), and several macrovascular risk factors was analyzed. RESULTS: F2-isoprostanes and CAC were unrelated to adiponectin after minimal adjustment for gender, race, and center. After additional adjustment for insulin resistance and waist circumference and other macrovascular risk factors, adiponectin correlated positively with high-density lipoprotein-cholesterol (p < 0.0001), F2-isoprostanes (p < 0.0001), and CAC (less strongly, p < 0.01) and negatively with triglycerides (p < 0.0001) and C-reactive protein (marking inflammation, p = 0.01). DISCUSSION: Although these data are consistent with reduced cardiovascular disease risk imparted by adiponectin, the higher circulating levels of adiponectin present with oxidative stress and CAC (adjusting for waist and insulin resistance) may indicate an enhanced adiponectin secretory response of adipose tissue to the metabolic environment present in the early development of macrovascular disease. Thus, the elevated levels of adiponectin may comprise an attempt to alleviate risk for additional development and progression of macrovascular disease in an at-risk environment.

Adiponectin, visceral fat, oxidative stress, and early macrovascular disease: the Coronary Artery Risk Development in Young Adults Study. Publishing Authors By Initials

MW Steffes,MD Gross,DH Lee,PJ Schreiner,DR Jacobs,

For similar cardiovascular diseases: vascular diseases research abstracts see: cardiovascular diseases: vascular diseases research

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Adiponectin, visceral fat, oxidative stress, and early macrovascular disease: the Coronary Artery Risk Development in Young Adults Study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Obesity (Silver Spring, Md.)

VOLUME: 14

Page Numbers: 319-26

Journal Abbreviation: Obesity (Silver Spring)

ISSN: 1930-7381

DAY: 21

MONTH: Feb

YEAR: 2006

Adiponectin, visceral fat, oxidative stress, and early macrovascular disease: the Coronary Artery Risk Development in Young Adults Study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101264860

Adiponectin, visceral fat, oxidative stress, and early macrovascular disease: the Coronary Artery Risk Development in Young Adults Study. Keywords Mesh Terms:

KEYWORDS: Vascular Diseases

MESH TERMS: pathology

Chemical & Substance for Abstract: Adiponectin, visceral fat, oxidative stress, and early macrovascular disease: the Coronary Artery Risk Development in Young Adults Study. Information

Substance Name: C-Reactive Protein

Registry Number: 9007-41-4

Grant and Affiliation Information for Adiponectin, visceral fat, oxidative stress, and early macrovascular disease: the Coronary Artery Risk Development in Young Adults Study.

AFFILIATION: Department of Laboratory Medicine and Pathology, School of Public Health, University of Minnesota, Minneapolis, MN, USA. steff001@umn.edu

Country: United States

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MEDLINETA: Obesity (Silver Spring)

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