Adiponectin incompletely prevent MCP-1-dependent restenosis after percutaneous coronary intervention in patients with coronary artery disease.

Adiponectin incompletely prevent MCP-1-dependent restenosis after percutaneous coronary intervention in patients with coronary artery disease. Research Abstract Details 

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Adiponectin incompletely prevent MCP-1-dependent restenosis after percutaneous coronary intervention in patients with coronary artery disease. Abstract Text:

Norihito Inami,Shosaku Nomura,Takayuki Shimazu,Kenichi Manabe,Yutaka Kimura,Toshiji Iwasaka,Norihito Inami,Shosaku Nomura,Takayuki Shimazu,Kenichi Manabe,Yutaka Kimura,Toshiji Iwasaka,

BACKGROUND: Some factors play pathogenic roles in the development of restenosis after percutaneous coronary intervention (PCI). We measured and compared the ratio of elevated levels of monocytic chemotactic peptide-1 (MCP-1), regulated on activation normally T-cell expressed and secreted (RANTES), soluble (s) P-selectin, sE-selectin and adiponectin after PCI. METHODS: Plasma levels of chemokines and soluble markers were measured before and 30 days after PCI in 96 patients (69 males and 27 females, aged 63 +/- 9 years) who underwent PCI and who had repeated angiograms at a 6-month follow-up. In addition, we carried out the basic study of the tissue factor expression on monocytic cell line (THP-1) by MCP-1. RESULTS: Restenosis occurred in 33 (34.4%) patients. A significant and time-dependent increase in MCP-1 was observed in the restenosis group. However, there were no significant differences in RANTES, sP-selectin, and sE-selectin levels with or without restenosis. Adiponectin levels in patients with coronary artery disease were significantly lower than levels in normal controls. However, adiponectin levels were no different at baseline between patients with or without restenosis. MCP-1 did not induce the expression of tissue factor on THP-1. However, the recombinant sCD40 ligand-induced expression of tissue factor on THP-1 was enhanced by the addition of MCP-1. CONCLUSION: These findings suggest that restenosis development after PCI in patients with coronary artery disease may involve the participation of MCP-1 after PCI, and adiponectin incompletely prevent this MCP-1-dependent restenosis.

Adiponectin incompletely prevent MCP-1-dependent restenosis after percutaneous coronary intervention in patients with coronary artery disease. Publishing Authors By Initials

N Inami,S Nomura,T Shimazu,K Manabe,Y Kimura,T Iwasaka,N Inami,S Nomura,T Shimazu,K Manabe,Y Kimura,T Iwasaka,

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Adiponectin incompletely prevent MCP-1-dependent restenosis after percutaneous coronary intervention in patients with coronary artery disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of thrombosis and thrombolysis

VOLUME: 24

Page Numbers: 267-73

Journal Abbreviation: J. Thromb. Thrombolysis

ISSN: 0929-5305

DAY: 8

MONTH: 05

YEAR: 2007

Adiponectin incompletely prevent MCP-1-dependent restenosis after percutaneous coronary intervention in patients with coronary artery disease. Information

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LANGUAGE: eng

NlmUniqueID: 9502018

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Grant and Affiliation Information for Adiponectin incompletely prevent MCP-1-dependent restenosis after percutaneous coronary intervention in patients with coronary artery disease.

AFFILIATION: Second Department of Internal Medicine, Kansai Medical University, Moriguchi, Osaka, Japan.

Country: Netherlands

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MEDLINETA: J Thromb Thrombolysis

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