Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism.

Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism. Abstract Text:

P M Catalano,M Hoegh,J Minium,L Huston-Presley,S Bernard,S Kalhan,S Hauguel-De Mouzon,

AIMS/HYPOTHESIS: Adiponectin is upregulated during adipogenesis and downregulated in insulin-resistant states. The mechanism(s) governing the re-arrangements from adipogenesis to facilitated lipolysis during pregnancy are unknown. Our purpose was to analyse the role of adiponectin relative to the metabolic changes in human pregnancy. SUBJECTS, MATERIALS AND METHODS: Lean women (BMI <25 kg/m(2)) were evaluated longitudinally before conception, and in early (12-14 weeks) and late (34-36 weeks) pregnancy. Insulin sensitivity was measured using the glucose clamp technique. Venous blood and subcutaneous adipose tissue biopsies were obtained at each time point. RESULTS: Adiponectin concentrations were lower in the third trimester than in the pregravid condition (9.9+/-1.4 vs 13.5+/-1.8 microg/ml). The hypoadiponectinaemia was reflected by a 2.5-fold decrease in white adipose tissue adiponectin mRNA. These changes were associated with a 25% increase in fat mass (23.7+/-2.9 vs 18.9+/-2.9 kg). Insulin infusion decreased high molecular weight adiponectin complexes in pregravid women (9.9+/-0.6 vs 6.2+/-0.06) and the suppressive effect of insulin was lost during pregnancy. The pregnancy-mediated changes in adiponectin were strongly correlated with basal insulin levels and insulin sensitivity (p<0.0001). The relationship between adiponectin and insulin sensitivity was related to the decreased insulin regulation of glucose utilisation (r=0.55, p<0.001) but not of endogenous hepatic glucose production. CONCLUSIONS/INTERPRETATION: These data demonstrate that pregnancy is associated with adiponectin changes in lean women. Hypoadiponectinaemia is reflected by a lower amount of high molecular weight adiponectin and by the ratio of high to low molecular weight multimers. The adiponectin changes relate to decreased insulin sensitivity of glucose disposal rather than alterations of lipid metabolism.

Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism. Publishing Authors By Initials

PM Catalano,M Hoegh,J Minium,L Huston-Presley,S Bernard,S Kalhan,S Hauguel-De Mouzon,

For similar reproductive and urinary physiology: reproduction: pregnancy research abstracts see: reproductive and urinary physiology: reproduction: pregnancy research

PUBMED ID PMID:

MEDLINE DATE:

Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Diabetologia

VOLUME: 49

Page Numbers: 1677-85

Journal Abbreviation: Diabetologia

ISSN: 0012-186X

DAY: 11

MONTH: 05

YEAR: 2006

Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 6777

Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism. Keywords Mesh Terms:

KEYWORDS: Pregnancy

MESH TERMS: metabolism

Chemical & Substance for Abstract: Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism. Information

Substance Name: Glucose

Registry Number: 50-99-7

Grant and Affiliation Information for Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism.

AFFILIATION: Department of Reproductive Biology, Case Western Reserve University, 2550 MetroHealth Drive, Cleveland, OH 44109, USA.

Country: Germany

AGENCY: United States NICHD

GRANT: R01 HD022965

ACRONYM: HD

MEDLINETA: Diabetologia

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism Related Publications

• Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism.
• High molecular mass multimer complexes and vascular expression contribute to high adiponectin in the fetus.
• Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta.