Adiponectin and its correlates of cardiovascular risk in young adults: the Bogalusa Heart Study.

Adiponectin and its correlates of cardiovascular risk in young adults: the Bogalusa Heart Study. Research Abstract Details 

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Adiponectin and its correlates of cardiovascular risk in young adults: the Bogalusa Heart Study. Abstract Text:

Dharmendrakumar A Patel,Sathanur R Srinivasan,Ji-Hua Xu,Wei Chen,Gerald S Berenson,

Adiponectin, a novel adipocytokine produced exclusively in the adipose tissue, plays a major role in the development of metabolic syndrome, type 2 diabetes mellitus, and related cardiovascular (CV) diseases. However, information is scant regarding the association of adiponectin with measures of CV risk in young adults. This aspect was examined in a biracial (black-white) community-based sample of 1153 individuals (mean age, 36.2 years; 70% white, 43% male) who participated in the Bogalusa Heart Study. Adiponectin levels showed race (white > black, P < .0001) and sex (female > male, P < .0001) differences, and correlated significantly in a beneficial manner to measures of obesity (body mass index, waist circumference, and abdominal height), mean arterial blood pressure, lipoprotein variables (low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides), measures of glucose homeostasis (insulin, glucose, homeostasis model assessment of insulin resistance [HOMA-IR]), and uric acid, after adjusting for age, race, sex, and cigarette smoking. In multivariate analysis that used either body mass index or abdominal height as a measure of general and visceral adiposity in 2 separate models, HOMA-IR was the major contributor explaining 18.4% and 18.1% of the variance, respectively. There was a significant interaction between abdominal height and HOMA-IR on adiponectin level in that the inverse association between adiponectin and insulin resistance was pronounced at higher level of visceral adiposity. Furthermore, adiponectin levels decreased with increasing number of metabolic syndrome risk factors defined by the National Cholesterol Education Program Adult Treatment Panel III (P for trend <.0001). Moreover, adiponectin levels were low among those with positive parental histories of coronary heart disease (P = .03), hypertension (P = .04), and type 2 diabetes mellitus (P = .01), considered as surrogate measures of risk. These findings, by showing an inverse association of adiponectin with insulin resistance, visceral adiposity, and related metabolic syndrome, and also with positive parental histories of coronary heart disease, hypertension, and type 2 diabetes mellitus, underscore the value of adiponectin in CV and type 2 diabetes mellitus risk assessments in young adults.

Adiponectin and its correlates of cardiovascular risk in young adults: the Bogalusa Heart Study. Publishing Authors By Initials

DA Patel,SR Srinivasan,JH Xu,W Chen,GS Berenson,

For similar heterocyclic compounds: alkaloids: xanthines: uric acid research abstracts see: heterocyclic compounds: alkaloids: xanthines: uric acid research

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Adiponectin and its correlates of cardiovascular risk in young adults: the Bogalusa Heart Study. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Metabolism: clinical and experimental

VOLUME: 55

Page Numbers: 1551-7

Journal Abbreviation: Metab. Clin. Exp.

ISSN: 0026-0495

DAY: 3

MONTH: Nov

YEAR: 2006

Adiponectin and its correlates of cardiovascular risk in young adults: the Bogalusa Heart Study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375267

Adiponectin and its correlates of cardiovascular risk in young adults: the Bogalusa Heart Study. Keywords Mesh Terms:

KEYWORDS: Uric Acid

MESH TERMS: blood

Chemical & Substance for Abstract: Adiponectin and its correlates of cardiovascular risk in young adults: the Bogalusa Heart Study. Information

Substance Name: Uric Acid

Registry Number: 69-93-2

Grant and Affiliation Information for Adiponectin and its correlates of cardiovascular risk in young adults: the Bogalusa Heart Study.

AFFILIATION: Tulane Center for Cardiovascular Health, Tulane University Health Science Center, New Orleans, LA 70112, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL-38844

ACRONYM: HL

MEDLINETA: Metabolism

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