Adipogenic, osteogenic and myofibrogenic differentiations of a rat malignant fibrous histiocytoma (MFH)-derived cell line, and a relationship of MFH cells with embryonal mesenchymal, perivascular and bone marrow stem cells.

Adipogenic, osteogenic and myofibrogenic differentiations of a rat malignant fibrous histiocytoma (MFH)-derived cell line, and a relationship of MFH cells with embryonal mesenchymal, perivascular and bone marrow stem cells. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Adipogenic, osteogenic and myofibrogenic differentiations of a rat malignant fibrous histiocytoma (MFH)-derived cell line, and a relationship of MFH cells with embryonal mesenchymal, perivascular and bone marrow stem cells. Abstract Text:

Jyoji Yamate,Keiko Ogata,Takahiro Yuasa,Mitsuru Kuwamura,Shigeo Takenaka,Daijirou Kumagai,Kazuyuki Itoh,Jonathan Lamarre,Jyoji Yamate,Keiko Ogata,Takahiro Yuasa,Mitsuru Kuwamura,Shigeo Takenaka,Daijirou Kumagai,Kazuyuki Itoh,Jonathan LaMarre,

Malignant fibrous histiocytoma (MFH) is regarded as an undifferentiated pleomorphic sarcoma with unproven histogenesis. We investigated pathobiological characteristics of a rat MFH cell line (MT-9). Immunocytochemically, MT-9 cells and MT-9-induced tumours reacted to vimentin, A3 (rat MFH cell-specific antibody), macrophage markers and alpha-SMA (myofibroblastic marker), indicating that MT-9 showed both histiocytic and (myo)fibroblastic features. Adipogenic supplement-added MT-9 showed increased accumulation of lipid droplets. Addition of BMP-2 or osteogenic supplement to MT-9 enhanced osteoblastic markers (ALP activity, osteocalcin mRNA expression and calcification). TGF-beta1-treated MT-9 revealed increased numbers of alpha-SMA-immunopositive cells, and enhanced protein levels of alpha-SMA and fibronectin, indicating myofibrogenesis. In rat tissues, A3 labelled with immature mesenchymal and perivascular cells in foetuses and neonates, and with marrow stem cells in adults. c-kit mRNA expression was seen in bone marrows and MT-9. Collectively, progenitors of MFH should be sought in lineage of marrow stem cells capable of differentiating into mesenchymal cells.

Adipogenic, osteogenic and myofibrogenic differentiations of a rat malignant fibrous histiocytoma (MFH)-derived cell line, and a relationship of MFH cells with embryonal mesenchymal, perivascular and bone marrow stem cells. Publishing Authors By Initials

J Yamate,K Ogata,T Yuasa,M Kuwamura,S Takenaka,D Kumagai,K Itoh,J Lamarre,J Yamate,K Ogata,T Yuasa,M Kuwamura,S Takenaka,D Kumagai,K Itoh,J LaMarre,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Adipogenic, osteogenic and myofibrogenic differentiations of a rat malignant fibrous histiocytoma (MFH)-derived cell line, and a relationship of MFH cells with embryonal mesenchymal, perivascular and bone marrow stem cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of cancer (Oxford, England : 1990

VOLUME: 43

Page Numbers: 2747-56

Journal Abbreviation: Eur. J. Cancer

ISSN: 0959-8049

DAY: 30

MONTH: Dec

YEAR: 2007

Adipogenic, osteogenic and myofibrogenic differentiations of a rat malignant fibrous histiocytoma (MFH)-derived cell line, and a relationship of MFH cells with embryonal mesenchymal, perivascular and bone marrow stem cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9005373

Adipogenic, osteogenic and myofibrogenic differentiations of a rat malignant fibrous histiocytoma (MFH)-derived cell line, and a relationship of MFH cells with embryonal mesenchymal, perivascular and bone marrow stem cells. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Adipogenic, osteogenic and myofibrogenic differentiations of a rat malignant fibrous histiocytoma (MFH)-derived cell line, and a relationship of MFH cells with embryonal mesenchymal, perivascular and bone marrow stem cells. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Adipogenic, osteogenic and myofibrogenic differentiations of a rat malignant fibrous histiocytoma (MFH)-derived cell line, and a relationship of MFH cells with embryonal mesenchymal, perivascular and bone marrow stem cells.

AFFILIATION: Laboratory of Veterinary Pathology, Life and Environmental Sciences, Osaka Prefecture University, Gakuencho 1-1, Sakai, Osaka 599-8531, Japan.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Eur J Cancer

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Adipogenic, osteogenic and myofibrogenic differentiations of a rat malignant fibrous histiocytoma MFH-derived cell line, and a relationship of MFH cells with embryonal mesenchymal, perivascular and bone marrow stem cells Related Publications

• Activity of neurons in the lower precentral cortex during voluntary and rhythmical jaw movements in the monkey.
• Adipogenic, osteogenic and myofibrogenic differentiations of a rat malignant fibrous histiocytoma (MFH)-derived cell line, and a relationship of MFH cells with embryonal mesenchymal, perivascular and bone marrow stem cells.
• Control of single-joint movements in deafferented patients: evidence for amplitude coding rather than position control.
• In memoriam: professeur raoul senault.
• Initial agonist burst duration changes with movement amplitude in a deafferented patient.
• Modulation of lemniscal input during conditioned arm movements in the monkey.
• Modulation of somatosensory evoked responses in the primary somatosensory cortex produced by intracortical microstimulation of the motor cortex in the monkey.
• Modulation of the cutaneous responsiveness of neurones in the primary somatosensory cortex during conditioned arm movements in the monkey.
• Novel plant virus-based vaccine induces protective cytotoxic T-lymphocyte-mediated antiviral immunity through dendritic cell maturation.
• Photon noise in photometric instruments at far-infrared and submillimeter wavelengths.
• Prospective evaluation of the management of moderate to severe cellulitis with parenteral antibiotics at a paediatric day treatment centre.
• Reciprocal and coactivation commands for fast wrist movements.
• Reference systems for coding spatial information in normal subjects and a deafferented patient.
• Role of the feedforward command and reafferent information in the coordination of a passing prehension task.
• Spontaneous unit activity in motor and somesthetic cortices during the sleep-wakefulness cycles in the monkey.
• [Creating contexts of cooperation to get out of therapeutic deadlock.]