Adhesion between molecules and calcium oxalate crystals: critical interactions in kidney stone formation.

Adhesion between molecules and calcium oxalate crystals: critical interactions in kidney stone formation. Research Abstract Details 

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Adhesion between molecules and calcium oxalate crystals: critical interactions in kidney stone formation. Abstract Text:

Xiaoxia Sheng,Michael D Ward,Jeffrey A Wesson,

Kidney stones are crystal aggregates, most commonly containing calcium oxalate monohydrate (COM) crystals as the primary constituent. Notably, in vitro studies have suggested that anionic molecules or macromolecules with substantial anionic functionality (e.g., carboxylate) play an important role in crystal aggregation and crystal attachment to renal epithelial cells. Furthermore, kidney stones contain measurable amounts of carboxylate-rich proteins that may serve as adhesives and promote aggregation of COM crystals. Atomic force microscopy (AFM) measurements of adhesion forces between tip-immobilized molecules and the COM (100) surface in aqueous media, described herein, reveal the effect of functional groups on adhesion and support an important role for the carboxylate group in processes responsible for kidney stone formation, specifically macromolecule-mediated adhesion of COM crystals to cells and crystal aggregation. The presence of poly(aspartic acid) during force measurements results in a reduction in the adhesion force measured for carboxylate-modified tips, consistent with the blocking of binding sites on the COM (100) surface by the carboxylate-rich polymer. This competitive binding behavior mimics the known reduction in attachment of COM crystals to renal epithelial cells in the presence of carboxylate-rich urinary macromolecules. These results suggest a feasible methodology for identifying the most important crystal surface-macromolecule combinations related to stone formation.

Adhesion between molecules and calcium oxalate crystals: critical interactions in kidney stone formation. Publishing Authors By Initials

X Sheng,MD Ward,JA Wesson,

For similar diagnosis: diagnostic techniques and procedures: diagnostic imaging: microscopy: microscopy, scanning probe: microscopy, atomic force research abstracts see: diagnosis: diagnostic techniques and procedures: diagnostic imaging: microscopy: microscopy, scanning probe: microscopy, atomic force research

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Adhesion between molecules and calcium oxalate crystals: critical interactions in kidney stone formation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the American Chemical Society

VOLUME: 125

Page Numbers: 2854-5

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 12

MONTH: Mar

YEAR: 2003

Adhesion between molecules and calcium oxalate crystals: critical interactions in kidney stone formation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

Adhesion between molecules and calcium oxalate crystals: critical interactions in kidney stone formation. Keywords Mesh Terms:

KEYWORDS: Microscopy, Atomic Force

MESH TERMS: metabolism

Chemical & Substance for Abstract: Adhesion between molecules and calcium oxalate crystals: critical interactions in kidney stone formation. Information

Substance Name: Calcium Oxalate

Registry Number: 25454-23-3

Grant and Affiliation Information for Adhesion between molecules and calcium oxalate crystals: critical interactions in kidney stone formation.

AFFILIATION: Department of Chemical Engineering and Materials Science, University of Minnesota, 421 Washington Avenue SE, Minneapolis, Minnesota 55455, USA.

Country: United States

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MEDLINETA: J Am Chem Soc

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