Adhesin-dependent binding and uptake of Salmonella enterica serovar Typhimurium by dendritic cells.

Adhesin-dependent binding and uptake of Salmonella enterica serovar Typhimurium by dendritic cells. Research Abstract Details 

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Adhesin-dependent binding and uptake of Salmonella enterica serovar Typhimurium by dendritic cells. Abstract Text:

Aizhen Guo,Melissa A Lasaro,Jean-Claude Sirard,Jean-Pierre ,Dieter M Schifferli,

Salmonella enterica serovar Typhimurium can be internalized by immature dendritic cells (DCs). The interacting host and bacterial molecules initiating this process remain uncharacterized. The objective of this study was to investigate whether specific fimbriae are involved in the early step of binding and uptake of Salmonella by DCs. Type 1 fimbriated S. enterica serovar Typhimurium or recombinant Escherichia coli expressing the type 1 fimbriae showed a significantly greater ability to attach to murine bone-marrow-derived DCs than non-fimbriated bacteria. The FimH adhesin was required for efficient interactions with DCs, since fimbriated fimH mutants were impaired in both binding and internalization. Finally, the internalization involved a FimH-dependent process but did not require sipB, a gene essential for Salmonella-mediated invasion of mammalian epithelial cells. Collectively, these data suggest that the bacterial interaction of DCs through the type 1 fimbrial adhesin FimH is sufficient to target S. enterica serovar Typhimurium for cellular uptake.

Adhesin-dependent binding and uptake of Salmonella enterica serovar Typhimurium by dendritic cells. Publishing Authors By Initials

A Guo,MA Lasaro,JC Sirard,JP ,DM Schifferli,

For similar bacteria: gram-negative bacteria: gram-negative facultatively anaerobic rods: enterobacteriaceae: salmonella: salmonella enterica: salmonella typhimurium research abstracts see: bacteria: gram-negative bacteria: gram-negative facultatively anaerobic rods: enterobacteriaceae: salmonella: salmonella enterica: salmonella typhimurium research

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Adhesin-dependent binding and uptake of Salmonella enterica serovar Typhimurium by dendritic cells. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Microbiology (Reading, England)

VOLUME: 153

Page Numbers: 1059-69

Journal Abbreviation: Microbiology (Reading, Engl.)

ISSN: 1350-0872

DAY: 28

MONTH: Apr

YEAR: 2007

Adhesin-dependent binding and uptake of Salmonella enterica serovar Typhimurium by dendritic cells. Information

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LANGUAGE: eng

NlmUniqueID: 9430468

Adhesin-dependent binding and uptake of Salmonella enterica serovar Typhimurium by dendritic cells. Keywords Mesh Terms:

KEYWORDS: Salmonella typhimurium

MESH TERMS: metabolism

Chemical & Substance for Abstract: Adhesin-dependent binding and uptake of Salmonella enterica serovar Typhimurium by dendritic cells. Information

Substance Name: Fimbriae Proteins

Registry Number: 147680-16-8

Grant and Affiliation Information for Adhesin-dependent binding and uptake of Salmonella enterica serovar Typhimurium by dendritic cells.

AFFILIATION: University of Pennsylvania School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104, USA.

Country: England

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MEDLINETA: Microbiology

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