ADHD- and medication-related brain activation effects in concordantly affected parent-child dyads with ADHD.

ADHD- and medication-related brain activation effects in concordantly affected parent-child dyads with ADHD. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

ADHD- and medication-related brain activation effects in concordantly affected parent-child dyads with ADHD. Abstract Text:

Jeffery N Epstein,B J Casey,Simon T Tonev,Matthew C Davidson,Allan L Reiss,Amy Garrett,Stephen P Hinshaw,Laurence L Greenhill,Gary Glover,Keith M Shafritz,Alan Vitolo,Lisa A Kotler,Matthew A Jarrett,Julie Spicer,Jeffery N Epstein,B J Casey,Simon T Tonev,Matthew C Davidson,Allan L Reiss,Amy Garrett,Stephen P Hinshaw,Laurence L Greenhill,Gary Glover,Keith M Shafritz,Alan Vitolo,Lisa A Kotler,Matthew A Jarrett,Julie Spicer,

BACKGROUND: Several studies have documented fronto-striatal dysfunction in children and adolescents with attention deficit/hyperactivity disorder (ADHD) using response inhibition tasks. Our objective was to examine functional brain abnormalities among youths and adults with ADHD and to examine the relations between these neurobiological abnormalities and response to stimulant medication. METHOD: A group of concordantly diagnosed ADHD parent-child dyads was compared to a matched sample of normal parent-child dyads. In addition, ADHD dyads were administered double-blind methylphenidate and placebo in a counterbalanced fashion over two consecutive days of testing. Frontostriatal function was measured using functional magnetic resonance imaging (fMRI) during performance of a go/no-go task. RESULTS: Youths and adults with ADHD showed attenuated activity in fronto-striatal regions. In addition, adults with ADHD appeared to activate non-fronto-striatal regions more than normals. A stimulant medication trial showed that among youths, stimulant medication increased activation in fronto-striatal and cerebellar regions. In adults with ADHD, increases in activation were observed in the striatum and cerebellum, but not in prefrontal regions. CONCLUSIONS: This study extends findings of fronto-striatal dysfunction to adults with ADHD and highlights the importance of frontostriatal and frontocerebellar circuitry in this disorder, providing evidence of an endophenotype for examining the genetics of ADHD.

ADHD- and medication-related brain activation effects in concordantly affected parent-child dyads with ADHD. Publishing Authors By Initials

JN Epstein,BJ Casey,ST Tonev,MC Davidson,AL Reiss,A Garrett,SP Hinshaw,LL Greenhill,G Glover,KM Shafritz,A Vitolo,LA Kotler,MA Jarrett,J Spicer,JN Epstein,BJ Casey,ST Tonev,MC Davidson,AL Reiss,A Garrett,SP Hinshaw,LL Greenhill,G Glover,KM Shafritz,A Vitolo,LA Kotler,MA Jarrett,J Spicer,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

ADHD- and medication-related brain activation effects in concordantly affected parent-child dyads with ADHD. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of child psychology and psychiatry, and al

VOLUME: 48

Page Numbers: 899-913

Journal Abbreviation:

ISSN: 0021-9630

DAY: 23

MONTH: Sep

YEAR: 2007

ADHD- and medication-related brain activation effects in concordantly affected parent-child dyads with ADHD. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375361

ADHD- and medication-related brain activation effects in concordantly affected parent-child dyads with ADHD. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: ADHD- and medication-related brain activation effects in concordantly affected parent-child dyads with ADHD. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for ADHD- and medication-related brain activation effects in concordantly affected parent-child dyads with ADHD.

AFFILIATION: Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. jeff.epstein@cchmc.org

Country: England

AGENCY: United States NCRR

GRANT: RR09784

ACRONYM: RR

MEDLINETA: J Child Psychol Psychiatry

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

ADHD- and medication-related brain activation effects in concordantly affected parent-child dyads with ADHD Related Publications

• A method of estimating streptomycin in serum and other body fluids by diffusion through agar enclosed in glass tubes.
• A set of callipers for anatomical measurements.
• ADHD- and medication-related brain activation effects in concordantly affected parent-child dyads with ADHD.
• An investigation of the effects of material anisotropy and heterogeneity on pulsed, laser-generated acoustic signals.
• Assessment and prevention of head motion during imaging of patients with attention deficit hyperactivity disorder.
• Coexistence of acid phosphatase and acid mucosubstance in the nucleoid of human blood platelet granules.
• Comparison of medium- and high-energy collimators for 131I-tositumomab dosimetry.
• DENTAL CLUES TO MYASTHENIA GRAVIS.
• Developmental trajectories of personal and collective self-concept among American Indian adolescents.
• Ductal stent and cavo-atrial sac occlusion in an adult with profound cyanosis after palliated cyanotic congenital heart disease.
• Effect of para-aminobenzoic acid on the in vivo oxidation of hemoglobin.
• Effects of propionibacteria and yeast culture fed to steers on nutrient intake and site and extent of digestion.
• Epidermoid carcinoma in sebaceous cysts.
• Gut reaction by heartless shrimps: experimental evidence for the role of the gut in generating circulation before cardiac ontogeny.
• Issues in using state hospital discharge data in injury control research and surveillance.
• Kinetics of colloidal templating using emulsion drop consolidation.
• Mental health and substance abuse services to parents of children involved with child welfare: a study of racial and ethnic differences for American Indian parents.
• Multidimensional NMR spectroscopy for protein characterization and assignment inside cells.
• ON THE FORMATION OF CLEAR SPACES IN CORNEAL NEBULAE.
• Ocean acidification disrupts induced defences in the intertidal gastropod Littorina littorea.
• PMA induces stabilization of oncostatin M mRNA in human lymphoma U937 cells.
• Paradoxical hyperfixation of HMPAO in cerebral infarction.
• Parathyroid imaging with 99m Tc-sestamibi.
• Pediatric restrictive cardiomyopathy associated with a mutation in beta-myosin heavy chain.
• Phylogenetic relationships within an endemic group of Malagasy 'assassin spiders' (Araneae, Archaeidae): ancestral character reconstruction, convergent evolution and biogeography.
• Random alcohol testing reduced alcohol-involved fatal crashes of drivers of large trucks.
• Reduced mammographic density with use of a gonadotropin-releasing hormone agonist-based chemoprevention regimen in BRCA1 carriers.
• SALIVARY DUCTS BLOCKED. SUBMANDIBULAR SWELLING CAUSED BY DENTURES.
• Thermal tolerance, acclimatory capacity and vulnerability to global climate change.
• Twist1 dimer selection regulates cranial suture patterning and fusion.