Adenylyl cyclase isoforms as novel therapeutic targets: an exciting example of excitotoxicity neuroprotection.

Adenylyl cyclase isoforms as novel therapeutic targets: an exciting example of excitotoxicity neuroprotection. Research Abstract Details 

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Adenylyl cyclase isoforms as novel therapeutic targets: an exciting example of excitotoxicity neuroprotection. Abstract Text:

Val J Watts,

The use of transgenic animals lacking one or multiple adenylyl cyclase (AC) isoforms has provided significant information on the roles of AC-dependent signaling in the central nervous system. A recent study provides evidence that AC type 1 (AC1) might be important in glutamate-induced neuronal toxicity. However, the absolute AC specificity revealed in this study contrasts earlier work examining other forms of neurodegeneration. Nonetheless, these observations suggest that specific AC isoforms may represent novel targets for the treatment of central nervous system disorders. It is anticipated that such findings will help catalyze new drug discovery efforts to identify small-molecule modulators of individual AC isoforms.

Adenylyl cyclase isoforms as novel therapeutic targets: an exciting example of excitotoxicity neuroprotection. Publishing Authors By Initials

VJ Watts,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

PUBMED ID PMID:

MEDLINE DATE:

Adenylyl cyclase isoforms as novel therapeutic targets: an exciting example of excitotoxicity neuroprotection. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Molecular interventions

VOLUME: 7

Page Numbers: 70-3

Journal Abbreviation:

ISSN: 1534-0384

DAY: 3

MONTH: Apr

YEAR: 2007

Adenylyl cyclase isoforms as novel therapeutic targets: an exciting example of excitotoxicity neuroprotection. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101093789

Adenylyl cyclase isoforms as novel therapeutic targets: an exciting example of excitotoxicity neuroprotection. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: physiology

Chemical & Substance for Abstract: Adenylyl cyclase isoforms as novel therapeutic targets: an exciting example of excitotoxicity neuroprotection. Information

Substance Name: Adenylate Cyclase

Registry Number: EC 4.6.1.1

Grant and Affiliation Information for Adenylyl cyclase isoforms as novel therapeutic targets: an exciting example of excitotoxicity neuroprotection.

AFFILIATION: Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA. wattsv@pharmacy.purdue.edu

Country: United States

AGENCY: United States NIMH

GRANT: MH 060397

ACRONYM: MH

MEDLINETA: Mol Interv

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