Adenoviral vectors for gene therapy.

Adenoviral vectors for gene therapy. Research Abstract Details 

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Adenoviral vectors for gene therapy. Abstract Text:

Joanne T Douglas,

Vectors based on human adenovirus serotypes 2 (Ad2) and 5 (Ad5) of species C possess a number of features that have favored their widespread employment for gene delivery both in vitro and in vivo. However, the use of recombinant Ad2- and Ad5-based vectors for gene therapy also suffers from a number of disadvantages. These vectors possess the tropism of the parental viruses, which infect all cells that possess the appropriate surface receptors, precluding the targeting of specific cell types. Conversely, some cell types that represent important targets for gene transfer express only low levels of the cellular receptors, which lead to inefficient infection. Another major disadvantage of Ad2- and Ad5-based vectors in vivo is the elicitation of both an innate and an acquired immune response. Considerable attention has therefore been focused on strategies to overcome these limitations, thereby permitting the full potential of adenoviral vectors to be realized.

Adenoviral vectors for gene therapy. Publishing Authors By Initials

JT Douglas,

For similar animals: chordata: vertebrates: mammals: primates: haplorhini: catarrhini: hominidae: humans research abstracts see: animals: chordata: vertebrates: mammals: primates: haplorhini: catarrhini: hominidae: humans research

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Adenoviral vectors for gene therapy. Journal Published:

PUBLICATION TYPE: Review

Journal: Molecular biotechnology

VOLUME: 36

Page Numbers: 71-80

Journal Abbreviation: Mol. Biotechnol.

ISSN: 1073-6085

DAY: 3

MONTH: May

YEAR: 2007

Adenoviral vectors for gene therapy. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9423533

Adenoviral vectors for gene therapy. Keywords Mesh Terms:

KEYWORDS: Humans

MESH TERMS: metabolism

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Grant and Affiliation Information for Adenoviral vectors for gene therapy.

AFFILIATION: Division of Human Gene Therapy, Department of Medicine, and the Gene Therapy Center, University of Alabama at Birmingham, 901 19th Street South, BMR2 412, Birmingham, AL 35294, USA. Joanne.Douglas@ccc.uab.edu

Country: United States

AGENCY: United States NCI

GRANT: R01 CA108585

ACRONYM: CA

MEDLINETA: Mol Biotechnol

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