Adenosine-induced bronchoconstriction: comparison between nedocromil sodium and sodium cromoglycate.

Adenosine-induced bronchoconstriction: comparison between nedocromil sodium and sodium cromoglycate. Research Abstract Details 

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Adenosine-induced bronchoconstriction: comparison between nedocromil sodium and sodium cromoglycate. Abstract Text:

N Crimi,F Palermo,R Oliveri,B Cacopardo,C Vancheri,A Mistretta,

The purpose of this study was to compare the protective effect of nedocromil sodium with that of sodium cromoglycate against adenosine-induced bronchoconstriction in 15 asymptomatic asthmatic patients. Airways response was evaluated as FEV1 and adenosine was administered as an aerosol diluted in 0.9% saline to produce a concentration range of 0.03-4.00 mg/ml. When FEV1 was decreased by 20% of the post-saline value, inhalation was discontinued and the PD20 adenosine calculated. Patients were studied on four separate days. On the first day the adenosine challenge was performed and on subsequent days patients were pretreated with either placebo or test drug in a randomized double-blind manner. In this study both sodium cromoglycate and nedocromil sodium showed a significant protective effect against adenosine in comparison with placebo. Their activity was not related to a bronchodilator action. Nedocromil sodium showed a greater protective effect against adenosine challenge which may be indicative of a broader spectrum of activity against nonantigenic stimuli.

Adenosine-induced bronchoconstriction: comparison between nedocromil sodium and sodium cromoglycate. Publishing Authors By Initials

N Crimi,F Palermo,R Oliveri,B Cacopardo,C Vancheri,A Mistretta,

For similar diagnosis: diagnostic techniques and procedures: skin tests research abstracts see: diagnosis: diagnostic techniques and procedures: skin tests research

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Adenosine-induced bronchoconstriction: comparison between nedocromil sodium and sodium cromoglycate. Journal Published:

PUBLICATION TYPE: Randomized Controlled Trial

Journal: European journal of respiratory diseases. Suppleme

VOLUME: 147

Page Numbers: 258-62

Journal Abbreviation:

ISSN: 0106-4347

DAY: 21

MONTH: 02

YEAR: 1986

Adenosine-induced bronchoconstriction: comparison between nedocromil sodium and sodium cromoglycate. Information

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LANGUAGE: eng

NlmUniqueID: 8010618

Adenosine-induced bronchoconstriction: comparison between nedocromil sodium and sodium cromoglycate. Keywords Mesh Terms:

KEYWORDS: Skin Tests

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Adenosine-induced bronchoconstriction: comparison between nedocromil sodium and sodium cromoglycate. Information

Substance Name: Nedocromil

Registry Number: 69049-73-6

Grant and Affiliation Information for Adenosine-induced bronchoconstriction: comparison between nedocromil sodium and sodium cromoglycate.

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Country: DENMARK

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MEDLINETA: Eur J Respir Dis Suppl

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