Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation.

Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation. Abstract Text:

Courtney M Lappas,Yuan-Ji Day,Melissa A Marshall,Victor H Engelhard,Joel Linden,

Ischemia reperfusion injury results from tissue damage during ischemia and ongoing inflammation and injury during reperfusion. Liver reperfusion injury is reduced by lymphocyte depletion or activation of adenosine A2A receptors (A2ARs) with the selective agonist 4-{3-[6-amino-9-(5-ethylcarbamoyl-3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]- prop-2-ynyl}-cyclohexanecarboxylic acid methyl ester (ATL146e). We show that NKT cells are stimulated to produce interferon (IFN)-gamma by 2 h after the initiation of reperfusion, and the use of antibodies to deplete NK1.1-positive cells (NK and NKT) or to block CD1d-mediated glycolipid presentation to NKT cells replicates, but is not additive to, the protection afforded by ATL146e, as assessed by serum alanine aminotransferase elevation, histological necrosis, neutrophil accumulation, and serum IFN-gamma elevation. Reduced reperfusion injury observed in RAG-1 knockout (KO) mice is restored to the wild-type (WT) level by adoptive transfer of NKT cells purified from WT or A2AR KO mice but not IFN-gamma KO mice. Additionally, animals with transferred A2AR-/- NKT cells are not protected from hepatic reperfusion injury by ATL146e. In vitro, ATL146e potently inhibits both anti-CD3 and alpha-galactosylceramide-triggered production of IFN-gamma by NKT cells. These findings suggest that hepatic reperfusion injury is initiated by the CD1d-dependent activation of NKT cells, and the activation of these cells is inhibited by A2AR activation.

Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation. Publishing Authors By Initials

CM Lappas,YJ Day,MA Marshall,VH Engelhard,J Linden,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: lymphocyte subsets: t-lymphocyte subsets research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: lymphocyte subsets: t-lymphocyte subsets research

PUBMED ID PMID:

MEDLINE DATE:

Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of experimental medicine

VOLUME: 203

Page Numbers: 2639-48

Journal Abbreviation: J. Exp. Med.

ISSN: 0022-1007

DAY: 6

MONTH: 11

YEAR: 2006

Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985109

Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation. Keywords Mesh Terms:

KEYWORDS: T-Lymphocyte Subsets

MESH TERMS: metabolism

Chemical & Substance for Abstract: Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation. Information

Substance Name: Receptor, Adenosine A2A

Registry Number: 0

Grant and Affiliation Information for Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation.

AFFILIATION: Department of Pharmacology, University of Virginia, Charlottesville, VA 2290, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL37942

ACRONYM: HL

MEDLINETA: J Exp Med

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation Related Publications

• A role for the cytoplasmic adaptor protein Act1 in mediating IL-17 signaling.
• Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation.
• Aqueous photodegradation and toxicity of the polycyclic aromatic hydrocarbons fluorene, dibenzofuran, and dibenzothiophene.
• Axonal motility and its modulation by activity are branch-type specific in the intact adult cerebellum.
• Chlorine photolysis and subsequent OH radical production during UV treatment of chlorinated water.
• Complete recovery after five minutes of circulatory arrest; report of a case.
• Contribution of impaired early-stage visual processing to working memory dysfunction in adolescents with schizophrenia: a study with event-related potentials and functional magnetic resonance imaging.
• Death delusion.
• Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells.
• Efficiency of pyrimidine dimer formation in Escherichia coli across UV wavelengths.
• Exploring imperfect squeezing flow measurements in a teflon geometry for semisolid foods.
• Food Poisoning Due to Staphylococci: With Special Reference to Staphylococcus Agglutination by Normal Horse Serum.
• Hepatic PGC-1beta overexpression induces combined hyperlipidemia and modulates the response to PPARalpha activation.
• Incidence and prevalence of pseudoexfoliation and open-angle glaucoma in northern Sweden: I. Baseline report.
• Modulation of the expression of the transcription factor Max in rat retinal ganglion cells by a recombinant adeno-associated viral vector.
• Mouse spinal cord compression injury is reduced by either activation of the adenosine A2A receptor on bone marrow-derived cells or deletion of the A2A receptor on non-bone marrow-derived cells.
• Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes.
• Object- and direction-specific interference between manual and mental rotation.
• Optimizing Therapy for Vancomycin-Resistant Enterococci (VRE).
• Prognostic and therapeutic aspects of urogenital tuberculosis.
• Reconstructive surgery in peripheral occlusive arteriosclerosis. Indications, methods and primary results.
• Relation of blood volume to fat content of the body, and blood volume deficits, in surgical patients.
• Steroids in early ARDS?
• The consequences of response nonlinearities for interpretation of spectrotemporal receptive fields.
• The expression of Clostridium perfringens consensus beta2 toxin is associated with bovine enterotoxaemia syndrome.
• Thromboendarterectomy of the iliac and femoral arteries by the semi-closed method.
• Visual hallucinations in schizophrenia investigated with functional magnetic resonance imaging.
• [Not Available.]
• [Not Available.]
• cis effects in adeno-associated virus type 2 replication.