Additive effect of mPer1 and mPer2 antisense oligonucleotides on light-induced phase shift.

Additive effect of mPer1 and mPer2 antisense oligonucleotides on light-induced phase shift. Research Abstract Details 

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Additive effect of mPer1 and mPer2 antisense oligonucleotides on light-induced phase shift. Abstract Text:

H Wakamatsu,S Takahashi,T Moriya,S T Inouye,H Okamura,M Akiyama,S Shibata,

It is well known that light induces both mPer1 and mPer2 mRNA in the suprachiasmatic nucleus. We have reported that mPer1 antisense oligonucleotides (ODNs) inhibited the light-induced phase delays of mouse locomotor rhythm. In this study, we asked whether both or either mPer1 or mPer2 expression is necessary to induce the phase shift. We examined the effects of inhibition of mRNA expression on light-induced phase delays of mouse circadian behavior rhythm. Light-induced phase delays were moderately attenuated by microinjection of mPer1 or mPer2 antisense ODN, but not by mPer3 antisense or mPer1, mPer2 scrambled ODNs, whereas following simultaneous injection of both mPer1 and mPer2 antisense ODNs they disappeared. The present results suggest that acute induction of mPer1 and mPer2 gene play an additive effect on photic entrainment.

Additive effect of mPer1 and mPer2 antisense oligonucleotides on light-induced phase shift. Publishing Authors By Initials

H Wakamatsu,S Takahashi,T Moriya,ST Inouye,H Okamura,M Akiyama,S Shibata,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Additive effect of mPer1 and mPer2 antisense oligonucleotides on light-induced phase shift. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuroreport

VOLUME: 12

Page Numbers: 127-31

Journal Abbreviation: Neuroreport

ISSN: 0959-4965

DAY: 22

MONTH: Jan

YEAR: 2001

Additive effect of mPer1 and mPer2 antisense oligonucleotides on light-induced phase shift. Information

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LANGUAGE: eng

NlmUniqueID: 9100935

Additive effect of mPer1 and mPer2 antisense oligonucleotides on light-induced phase shift. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Additive effect of mPer1 and mPer2 antisense oligonucleotides on light-induced phase shift. Information

Substance Name: Transcription Factors

Registry Number: 0

Grant and Affiliation Information for Additive effect of mPer1 and mPer2 antisense oligonucleotides on light-induced phase shift.

AFFILIATION: Department of Pharmacology and Brain Science, School of Human Sciences, Waseda University, Tokorozawa, Saitama, Japan.

Country: England

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MEDLINETA: Neuroreport

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