Additional sex combs affects antennal development by means of spatially restricted repression of Antp and wg.

Additional sex combs affects antennal development by means of spatially restricted repression of Antp and wg. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Additional sex combs affects antennal development by means of spatially restricted repression of Antp and wg. Abstract Text:

Naomi Halachmi,Karen L Schulze,Adi Inbal,Adi Salzberg,

Additional sex combs (Asx) is thought to function in protein complexes of both the Trithorax and Polycomb groups, but very little is known about its developmental roles. Here, we present a detailed analysis of Asx's role in antennal development. We show that loss of Asx in the antennal disc causes a complex phenotype, which consists of distal antenna-to-leg transformations and outgrowth of ectopic leg-like appendages from the Dpp-expressing domain of the disc. Our analyses suggest that these phenotypes are caused mainly by segment-specific de-repression of Antp and expansion of wg expression. We thus conclude that Asx functions normally to repress Antp and to restrict wg expression in specific regions of the developing disc. We also show that, in the absence of Asx's function, Antp expression does not lead to efficient repression of the antennal-determining gene hth, suggesting that Asx is also required for the repression of hth by Antp.

Additional sex combs affects antennal development by means of spatially restricted repression of Antp and wg. Publishing Authors By Initials

N Halachmi,KL Schulze,A Inbal,A Salzberg,

For similar proteins: transcription factors: repressor proteins research abstracts see: proteins: transcription factors: repressor proteins research

PUBMED ID PMID:

MEDLINE DATE:

Additional sex combs affects antennal development by means of spatially restricted repression of Antp and wg. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Developmental dynamics : an official publication o

VOLUME: 236

Page Numbers: 2118-30

Journal Abbreviation: Dev. Dyn.

ISSN: 1058-8388

DAY: 28

MONTH: Aug

YEAR: 2007

Additional sex combs affects antennal development by means of spatially restricted repression of Antp and wg. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9201927

Additional sex combs affects antennal development by means of spatially restricted repression of Antp and wg. Keywords Mesh Terms:

KEYWORDS: Repressor Proteins

MESH TERMS: physiology

Chemical & Substance for Abstract: Additional sex combs affects antennal development by means of spatially restricted repression of Antp and wg. Information

Substance Name: wingless protein, Drosophila

Registry Number: 117758-26-6

Grant and Affiliation Information for Additional sex combs affects antennal development by means of spatially restricted repression of Antp and wg.

AFFILIATION: Department of Genetics, Rappaport Family Institute for Research in the Medical Sciences, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Dev Dyn

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Additional sex combs affects antennal development by means of spatially restricted repression of Antp and wg Related Publications

• A computational survey of candidate exonic splicing enhancer motifs in the model plant Arabidopsis thaliana.
• A mechanical spike accompanies the action potential in Mammalian nerve terminals.
• A unified model explaining the offsets of overlapping and near-overlapping prokaryotic genes.
• Additional sex combs affects antennal development by means of spatially restricted repression of Antp and wg.
• Bioinformatics challenges of new sequencing technology.
• Hawkeye: an interactive visual analytics tool for genome assemblies.
• Human K10 epithelial keratin is the most abundant protein in airborne dust of both occupied and unoccupied school rooms.
• Identifying bacterial genes and endosymbiont DNA with Glimmer.
• Is RAS Blockade Routinely Indicated in Hypertensive Kidney Transplant Patients?
• It is time to end the patenting of software.
• JIGSAW, GeneZilla, and GlimmerHMM: puzzling out the features of human genes in the ENCODE regions.
• Posterior tuberculous sinuses of vertebral origin; wound revision and closure with streptomycin permitting early spinal fusion.
• Rapid, accurate, computational discovery of Rho-independent transcription terminators illuminates their relationship to DNA uptake.
• Re-assembly of the genome of Francisella tularensis subsp. holarctica OSU18.
• Subcutaneous mastectomy and immediate reconstruction for prevention of breast cancer for high-risk patients.
• The contents of the syringe.
• The neurologist, psychogenic nonepileptic seizures, and borderline personality disorder.
• The use of streptomycin in thoracoplasty for pulmonary tuberculosis.
• Transtracheal anesthesia for bronchoscopy.
• Two-photon excitation of potentiometric probes enables optical recording of action potentials from Mammalian nerve terminals in situ.
• Using GlimmerM to Find Genes in Eukaryotic Genomes.
• [Humana banana cereal in daily practice]
• [Treatment of acute diarrhea in pediatrics with Streptococcus faecium: results of a double blind study]