Addition of p-azido-L-phenylalanine to the genetic code of Escherichia coli.

Addition of p-azido-L-phenylalanine to the genetic code of Escherichia coli. Research Abstract Details 

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Addition of p-azido-L-phenylalanine to the genetic code of Escherichia coli. Abstract Text:

Jason W Chin,Stephen W Santoro,Andrew B Martin,David S King,Lei Wang,Peter G Schultz,

We report the selection of a new orthogonal aminoacyl tRNA synthetase/tRNA pair for the in vivo incorporation of a photocrosslinker, p-azido-l-phenylalanine, into proteins in response to the amber codon, TAG. The amino acid is incorporated in good yield with high fidelity and can be used to crosslink interacting proteins.

Addition of p-azido-L-phenylalanine to the genetic code of Escherichia coli. Publishing Authors By Initials

JW Chin,SW Santoro,AB Martin,DS King,L Wang,PG Schultz,

For similar enzymes and coenzymes: enzymes: ligases: carbon-oxygen ligases: amino acyl-trna synthetases: tyrosine-trna ligase research abstracts see: enzymes and coenzymes: enzymes: ligases: carbon-oxygen ligases: amino acyl-trna synthetases: tyrosine-trna ligase research

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Addition of p-azido-L-phenylalanine to the genetic code of Escherichia coli. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 124

Page Numbers: 9026-7

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 7

MONTH: Aug

YEAR: 2002

Addition of p-azido-L-phenylalanine to the genetic code of Escherichia coli. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

Addition of p-azido-L-phenylalanine to the genetic code of Escherichia coli. Keywords Mesh Terms:

KEYWORDS: Tyrosine-tRNA Ligase

MESH TERMS: metabolism

Chemical & Substance for Abstract: Addition of p-azido-L-phenylalanine to the genetic code of Escherichia coli. Information

Substance Name: Tyrosine-tRNA Ligase

Registry Number: EC 6.1.1.1

Grant and Affiliation Information for Addition of p-azido-L-phenylalanine to the genetic code of Escherichia coli.

AFFILIATION: Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Country: United States

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MEDLINETA: J Am Chem Soc

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