Addition of deoxynucleosides enhances human immunodeficiency virus type 1 integration and 2LTR formation in resting CD4+ T cells.

Addition of deoxynucleosides enhances human immunodeficiency virus type 1 integration and 2LTR formation in resting CD4+ T cells. Research Abstract Details 

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Addition of deoxynucleosides enhances human immunodeficiency virus type 1 integration and 2LTR formation in resting CD4+ T cells. Abstract Text:

Gabriela Plesa,Jihong Dai,Cliff Baytop,James L Riley,Carl H June,Una O'Doherty,Gabriela Plesa,Jihong Dai,Cliff Baytop,James L Riley,Carl H June,Una O'Doherty,

Resting CD4(+) T cells restrict human immunodeficiency virus (HIV) infection at a step prior to integration. Despite this restriction, we showed previously that HIV integration occurs in resting CD4(+) T cells in vitro, albeit at lower levels than in activated CD4(+) T cells. Here we show that addition of deoxynucleosides enhanced integration and 2LTR formation in resting CD4(+) T cells but that the kinetics were still significantly delayed compared to those of activated T cells. Thus, deoxynucleoside addition partially overcomes the restriction to HIV infection in resting CD4(+) T cells.

Addition of deoxynucleosides enhances human immunodeficiency virus type 1 integration and 2LTR formation in resting CD4+ T cells. Publishing Authors By Initials

G Plesa,J Dai,C Baytop,JL Riley,CH June,U O'Doherty,G Plesa,J Dai,C Baytop,JL Riley,CH June,U O'Doherty,

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Addition of deoxynucleosides enhances human immunodeficiency virus type 1 integration and 2LTR formation in resting CD4+ T cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of virology

VOLUME: 81

Page Numbers: 13938-42

Journal Abbreviation: J. Virol.

ISSN: 1098-5514

DAY: 10

MONTH: 10

YEAR: 2007

Addition of deoxynucleosides enhances human immunodeficiency virus type 1 integration and 2LTR formation in resting CD4+ T cells. Information

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LANGUAGE: eng

NlmUniqueID: 113724

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Grant and Affiliation Information for Addition of deoxynucleosides enhances human immunodeficiency virus type 1 integration and 2LTR formation in resting CD4+ T cells.

AFFILIATION: Department of Pathology and Laboratory Medicine, Division of Transfusion Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Country: United States

AGENCY: United States NIAID

GRANT: R21AI64031-A1

ACRONYM: AI

MEDLINETA: J Virol

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