Adaptive two-stage analysis of genetic association in case-control designs.

Adaptive two-stage analysis of genetic association in case-control designs. Research Abstract Details 

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Adaptive two-stage analysis of genetic association in case-control designs. Abstract Text:

Gang Zheng,Kijoung Song,Robert C Elston,

We study a two-stage analysis of genetic association for case-control studies. In the first stage, we compare Hardy-Weinberg disequilibrium coefficients between cases and controls and, in the second stage, we apply the Cochran- Armitage trend test. The two analyses are statistically independent when Hardy-Weinberg equilibrium holds in the population, so all the samples are used in both stages. The significance level in the first stage is adaptively determined based on its conditional power. Given the level in the first stage, the level for the second stage analysis is determined with the overall Type I error being asymptotically controlled. For finite sample sizes, a parametric bootstrap method is used to control the overall Type I error rate. This two-stage analysis is often more powerful than the Cochran-Armitage trend test alone for a large association study. The new approach is applied to SNPs from a real study.

Adaptive two-stage analysis of genetic association in case-control designs. Publishing Authors By Initials

G Zheng,K Song,RC Elston,

For similar genetic phenomena: variation (genetics): polymorphism, genetic: polymorphism, single nucleotide research abstracts see: genetic phenomena: variation (genetics): polymorphism, genetic: polymorphism, single nucleotide research

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Adaptive two-stage analysis of genetic association in case-control designs. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Human heredity

VOLUME: 63

Page Numbers: 175-86

Journal Abbreviation: Hum. Hered.

ISSN: 0001-5652

DAY: 19

MONTH: 02

YEAR: 2007

Adaptive two-stage analysis of genetic association in case-control designs. Information

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LANGUAGE: eng

NlmUniqueID: 200525

Adaptive two-stage analysis of genetic association in case-control designs. Keywords Mesh Terms:

KEYWORDS: Polymorphism, Single Nucleotide

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Grant and Affiliation Information for Adaptive two-stage analysis of genetic association in case-control designs.

AFFILIATION: Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA. zhengg@nhlbi.nih.gov

Country: Switzerland

AGENCY: United States NCRR

GRANT: RR03655

ACRONYM: RR

MEDLINETA: Hum Hered

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