Adaptive responses to creatine loading and exercise in fast-twitch rat skeletal muscle.

Adaptive responses to creatine loading and exercise in fast-twitch rat skeletal muscle. Research Abstract Details 

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Adaptive responses to creatine loading and exercise in fast-twitch rat skeletal muscle. Abstract Text:

Maria Gallo,Ian Maclean,Neil Tyreman,Karen J B Martins,Daniel Syrotuik,Tessa Gordon,Charles T Putman,

We investigated the effects of chronic creatine loading and voluntary running (Run) on muscle fiber types, proteins that regulate intracellular Ca(2+), and the metabolic profile in rat plantaris muscle to ascertain the bases for our previous observations that creatine loading results in a higher proportion of myosin heavy chain (MHC) IIb, without corresponding changes in contractile properties. Forty Sprague-Dawley rats were assigned to one of four groups: creatine-fed sedentary, creatine-fed run-trained, control-fed sedentary, and control-fed run-trained animals. Proportion and cross-sectional area increased 10% and 15% in type IIb fibers and the proportion of type IIa fibers decreased 11% in the creatine-fed run-trained compared with the control-fed run-trained group (P < 0.03). No differences were observed in fast Ca(2+)-ATPase isoform SERCA1 content (P > 0.49). Creatine feeding alone induced a 41% increase (P < 0.03) in slow Ca(2+)-ATPase (SERCA2) content, which was further elevated by 33% with running (P < 0.02). Run training alone reduced parvalbumin content by 50% (P < 0.05). By comparison, parvalbumin content was dramatically decreased by 75% (P < 0.01) by creatine feeding alone but was not further reduced by run training. These adaptive changes indicate that elevating the capacity for high-energy phosphate shuttling, through creatine loading, alleviates the need for intracellular Ca(2+) buffering by parvalbumin and increases the efficiency of Ca(2+) uptake by SERCAs. Citrate synthase and 3-hydroxyacyl-CoA dehydrogenase activities were elevated by run training (P < 0.003) but not by run training + creatine feeding. This indicates that creatine loading during run training supports a faster muscle phenotype that is adequately supported by the existing glycolytic potential, without changes in the capacity for terminal substrate oxidation.

Adaptive responses to creatine loading and exercise in fast-twitch rat skeletal muscle. Publishing Authors By Initials

M Gallo,I Maclean,N Tyreman,KJ Martins,D Syrotuik,T Gordon,CT Putman,

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Adaptive responses to creatine loading and exercise in fast-twitch rat skeletal muscle. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: American journal of physiology. Regulatory, integr

VOLUME: 294

Page Numbers: R1319-28

Journal Abbreviation: Am. J. Physiol. Regul. Integr.

ISSN: 0363-6119

DAY: 23

MONTH: 01

YEAR: 2008

Adaptive responses to creatine loading and exercise in fast-twitch rat skeletal muscle. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Adaptive responses to creatine loading and exercise in fast-twitch rat skeletal muscle.

AFFILIATION: E-417 Van Vliet Centre, Univ. of Alberta, Edmonton, AB, Canada T6G 2H9. tputman@ualberta.ca).

Country: United States

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MEDLINETA: Am J Physiol Regul Integr Comp

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