Adaptive optics-optical coherence tomography: optimizing visualization of microscopic retinal structures in three dimensions.

Adaptive optics-optical coherence tomography: optimizing visualization of microscopic retinal structures in three dimensions. Research Abstract Details 

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Adaptive optics-optical coherence tomography: optimizing visualization of microscopic retinal structures in three dimensions. Abstract Text:

Robert J Zawadzki,Stacey S Choi,Steven M Jones,Scot S Oliver,John S Werner,

Adaptive optics-optical coherence tomography (AO-OCT) permits improved imaging of microscopic retinal structures by combining the high lateral resolution of AO with the high axial resolution of OCT, resulting in the narrowest three-dimensional (3D) point-spread function (PSF) of all in vivo retinal imaging techniques. Owing to the high volumetric resolution of AO-OCT systems, it is now possible, for the first time, to acquire images of 3D cellular structures in the living retina. Thus, with AO-OCT, those retinal structures that are not visible with AO or OCT alone (e.g., bundles of retinal nerve fiber layers, 3D mosaic of photoreceptors, 3D structure of microvasculature, and detailed structure of retinal disruptions) can be visualized. Our current AO-OCT instrumentation uses spectrometer-based Fourier-domain OCT technology and two-deformable-mirror-based AO wavefront correction. We describe image processing methods that help to remove motion artifacts observed in volumetric data, followed by innovative data visualization techniques [including two-dimensional (2D) and 3D representations]. Finally, examples of microscopic retinal structures that are acquired with the University of California Davis AO-OCT system are presented.

Adaptive optics-optical coherence tomography: optimizing visualization of microscopic retinal structures in three dimensions. Publishing Authors By Initials

RJ Zawadzki,SS Choi,SM Jones,SS Oliver,JS Werner,

For similar diagnosis: diagnostic techniques and procedures: diagnostic imaging: tomography: tomography, optical: tomography, optical coherence research abstracts see: diagnosis: diagnostic techniques and procedures: diagnostic imaging: tomography: tomography, optical: tomography, optical coherence research

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Adaptive optics-optical coherence tomography: optimizing visualization of microscopic retinal structures in three dimensions. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the Optical Society of America. A, Opti

VOLUME: 24

Page Numbers: 1373-83

Journal Abbreviation:

ISSN: 1084-7529

DAY: 3

MONTH: May

YEAR: 2007

Adaptive optics-optical coherence tomography: optimizing visualization of microscopic retinal structures in three dimensions. Information

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LANGUAGE: eng

NlmUniqueID: 9800943

Adaptive optics-optical coherence tomography: optimizing visualization of microscopic retinal structures in three dimensions. Keywords Mesh Terms:

KEYWORDS: Tomography, Optical Coherence

MESH TERMS: methods

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Grant and Affiliation Information for Adaptive optics-optical coherence tomography: optimizing visualization of microscopic retinal structures in three dimensions.

AFFILIATION: Department of Ophthalmology and Vision Science, Vision Science and Advanced Retinal Imaging Laboratory, University of California Davis, Sacramento 95817, USA.

Country: United States

AGENCY: United States NEI

GRANT: EY 014743

ACRONYM: EY

MEDLINETA: J Opt Soc Am A Opt Image Sci V

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