Adaptations in urea ammonium excretion in metabolic acidosis in the rat: a reinterpretation.

Adaptations in urea ammonium excretion in metabolic acidosis in the rat: a reinterpretation. Research Abstract Details 

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Adaptations in urea ammonium excretion in metabolic acidosis in the rat: a reinterpretation. Abstract Text:

J Oliver,E Bourke,

1. The effects of oral hydrochloric acid, ammonium chloride, sodium bicarbonate and ammonium bicarbonate on urea and ammonium excretion in rats on a constant diet were studied. 2. Hydrochloric acid acidosis significantly reduced urea excretion in the rat, with an equimolar increase in NH+4 excretion and no change in their sum. In ammonium chloride acidosis, most of the additional nitrogen intake is excreted as NH+4 and a small percentage as urea. The converse holds true after administration of ammonium bicarbonate. The physiological significance of this is discussed. 3. The shift in nitrogen excretion from urea to NH+4 in acidosis is interpreted on the basis of bicarbonate production and utilization. Urea formation utilizes HCO-3. For amino acid sources, this utilization is offset by the metabolism of the carbon skeleton, which gives rise to HCO-3. When waste nitrogen is excreted as NH+4, no bicarbonate is utilized and the new HCO-3, generated by the carbon skeleton, hels to maintain hydrogen ion homeostasis.

Adaptations in urea ammonium excretion in metabolic acidosis in the rat: a reinterpretation. Publishing Authors By Initials

J Oliver,E Bourke,

For similar organic chemicals: urea research abstracts see: organic chemicals: urea research

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Adaptations in urea ammonium excretion in metabolic acidosis in the rat: a reinterpretation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical science and molecular medicine. Supplemen

VOLUME: 48

Page Numbers: 515-10

Journal Abbreviation:

ISSN: 0144-4107

DAY: 12

MONTH: Jun

YEAR: 1975

Adaptations in urea ammonium excretion in metabolic acidosis in the rat: a reinterpretation. Information

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LANGUAGE: eng

NlmUniqueID: 7907311

Adaptations in urea ammonium excretion in metabolic acidosis in the rat: a reinterpretation. Keywords Mesh Terms:

KEYWORDS: Urea

MESH TERMS: urine

Chemical & Substance for Abstract: Adaptations in urea ammonium excretion in metabolic acidosis in the rat: a reinterpretation. Information

Substance Name: Hydrochloric Acid

Registry Number: 7647-01-0

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Country: ENGLAND

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MEDLINETA: Clin Sci Mol Med Suppl

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