Adaptation of energy metabolism in breast cancer brain metastases.

Adaptation of energy metabolism in breast cancer brain metastases. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Adaptation of energy metabolism in breast cancer brain metastases. Abstract Text:

Emily I Chen,Johannes Hewel,Joseph S Krueger,Claire Tiraby,Martin R Weber,Anastasia Kralli,Katja Becker,John R Yates,Brunhilde Felding-Habermann,

Brain metastases are among the most feared complications in breast cancer, as no therapy exists that prevents or eliminates breast cancer spreading to the brain. New therapeutic strategies depend on specific knowledge of tumor cell properties that allow breast cancer cell growth within the brain tissue. To provide information in this direction, we established a human breast cancer cell model for brain metastasis based on circulating tumor cells from a breast cancer patient and variants of these cells derived from bone or brain lesions in immunodeficient mice. The brain-derived cells showed an increased potential for brain metastasis in vivo and exhibited a unique protein expression profile identified by large-scale proteomic analysis. This protein profile is consistent with either a selection of predisposed cells or bioenergetic adaptation of the tumor cells to the unique energy metabolism of the brain. Increased expression of enzymes involved in glycolysis, tricarboxylic acid cycle, and oxidative phosphorylation pathways suggests that the brain metastatic cells derive energy from glucose oxidation. The cells further showed enhanced activation of the pentose phosphate pathway and the glutathione system, which can minimize production of reactive oxygen species resulting from an enhanced oxidative metabolism. These changes promoted resistance of brain metastatic cells to drugs that affect the cellular redox balance. Importantly, the metabolic alterations are associated with strongly enhanced tumor cell survival and proliferation in the brain microenvironment. Thus, our data support the hypothesis that predisposition or adaptation of the tumor cell energy metabolism is a key element in breast cancer brain metastasis, and raise the possibility of targeting the functional differentiation in breast cancer brain lesions as a novel therapeutic strategy.

Adaptation of energy metabolism in breast cancer brain metastases. Publishing Authors By Initials

EI Chen,J Hewel,JS Krueger,C Tiraby,MR Weber,A Kralli,K Becker,JR Yates,B Felding-Habermann,

For similar biological sciences: biochemistry: proteomics research abstracts see: biological sciences: biochemistry: proteomics research

PUBMED ID PMID:

MEDLINE DATE:

Adaptation of energy metabolism in breast cancer brain metastases. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cancer research

VOLUME: 67

Page Numbers: 1472-86

Journal Abbreviation: Cancer Res.

ISSN: 0008-5472

DAY: 15

MONTH: Feb

YEAR: 2007

Adaptation of energy metabolism in breast cancer brain metastases. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2984705

Adaptation of energy metabolism in breast cancer brain metastases. Keywords Mesh Terms:

KEYWORDS: Proteomics

MESH TERMS: metabolism

Chemical & Substance for Abstract: Adaptation of energy metabolism in breast cancer brain metastases. Information

Substance Name: Glutathione

Registry Number: 70-18-8

Grant and Affiliation Information for Adaptation of energy metabolism in breast cancer brain metastases.

AFFILIATION: Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. emilyc@scripps.edu

Country: United States

AGENCY: United States NIAID

GRANT: U19 AI 063603-02

ACRONYM: AI

MEDLINETA: Cancer Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Adaptation of energy metabolism in breast cancer brain metastases Related Publications

• Adaptation of energy metabolism in breast cancer brain metastases.