Acyl coenzyme A-binding protein augments bid-induced mitochondrial damage and cell death by activating mu-calpain.

Acyl coenzyme A-binding protein augments bid-induced mitochondrial damage and cell death by activating mu-calpain. Research Abstract Details 

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Acyl coenzyme A-binding protein augments bid-induced mitochondrial damage and cell death by activating mu-calpain. Abstract Text:

Nataly Shulga,John G Pastorino,

Activation of calpain has been shown to occur in some contexts of cell injury and to be essential for loss of cell viability. Part of this may be mediated at the mitochondrial level. It has been demonstrated that calpain activity is necessary for the complete discharge of apoptosis-inducing factor from the mitochondrial intermembrane space and can cause the cleavage of full-length Bid to a more potent truncated form (Polster, B. M., Basanez, G., Etxebarria, A., Hardwick, J. M., and Nicholls, D. G. (2005) J. Biol. Chem. 280, 6447-6454). In this study, we identify acyl-CoA-binding protein (ACBP) as playing a critical role in the activation of calpain upon exposure of mitochondria to both full-length Bid and truncated Bid (t-Bid). Suppression of ACBP levels by small interfering RNA inhibited the t-Bid-induced activation of mitochondrial mu-calpain and release of apoptosis-inducing factor from the mitochondrial intermembrane space and the cleavage of full-length Bid to t-Bid. Moreover, ACBP required the presence of the peripheral benzodiazepine receptor (for which ACBP is a ligand) to be retained at the mitochondria, to activate mu-calpain, and to amplify Bid-induced mitochondrial damage.

Acyl coenzyme A-binding protein augments bid-induced mitochondrial damage and cell death by activating mu-calpain. Publishing Authors By Initials

N Shulga,JG Pastorino,

For similar proteins: recombinant proteins research abstracts see: proteins: recombinant proteins research

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Acyl coenzyme A-binding protein augments bid-induced mitochondrial damage and cell death by activating mu-calpain. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of biological chemistry

VOLUME: 281

Page Numbers: 30824-33

Journal Abbreviation: J. Biol. Chem.

ISSN: 0021-9258

DAY: 14

MONTH: 08

YEAR: 2006

Acyl coenzyme A-binding protein augments bid-induced mitochondrial damage and cell death by activating mu-calpain. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985121

Acyl coenzyme A-binding protein augments bid-induced mitochondrial damage and cell death by activating mu-calpain. Keywords Mesh Terms:

KEYWORDS: Recombinant Proteins

MESH TERMS: chemistry

Chemical & Substance for Abstract: Acyl coenzyme A-binding protein augments bid-induced mitochondrial damage and cell death by activating mu-calpain. Information

Substance Name: mu-calpain

Registry Number: EC 3.4.22.-

Grant and Affiliation Information for Acyl coenzyme A-binding protein augments bid-induced mitochondrial damage and cell death by activating mu-calpain.

AFFILIATION: Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

Country: United States

AGENCY: United States NIAAA

GRANT: 5K01 AA000330-05

ACRONYM: AA

MEDLINETA: J Biol Chem

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