Acyclic stereoselective boron alkylation reactions for the asymmetric synthesis of beta-substituted alpha-amino acid derivatives.

Acyclic stereoselective boron alkylation reactions for the asymmetric synthesis of beta-substituted alpha-amino acid derivatives. Research Abstract Details 

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Acyclic stereoselective boron alkylation reactions for the asymmetric synthesis of beta-substituted alpha-amino acid derivatives. Abstract Text:

Martin J O'Donnell,Jeremy T Cooper,Mary M Mader,

Optically active syn- or anti-beta-substituted-alpha-amino acid derivatives are prepared in 94 to >/=99% ee and 66-98% ds by reaction of the Schiff base acetate of glycine tert-butyl ester with chiral, nonracemic B-alkyl-9-BBN derivatives in the presence of the Cinchona alkaloid, cinchonidine (CdOH) or cinchonine (CnOH), base, and lithium chloride.

Acyclic stereoselective boron alkylation reactions for the asymmetric synthesis of beta-substituted alpha-amino acid derivatives. Publishing Authors By Initials

MJ O'Donnell,JT Cooper,MM Mader,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: substrate specificity research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: substrate specificity research

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Acyclic stereoselective boron alkylation reactions for the asymmetric synthesis of beta-substituted alpha-amino acid derivatives. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 125

Page Numbers: 2370-1

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 5

MONTH: Mar

YEAR: 2003

Acyclic stereoselective boron alkylation reactions for the asymmetric synthesis of beta-substituted alpha-amino acid derivatives. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

Acyclic stereoselective boron alkylation reactions for the asymmetric synthesis of beta-substituted alpha-amino acid derivatives. Keywords Mesh Terms:

KEYWORDS: Substrate Specificity

MESH TERMS: analogs & derivatives

Chemical & Substance for Abstract: Acyclic stereoselective boron alkylation reactions for the asymmetric synthesis of beta-substituted alpha-amino acid derivatives. Information

Substance Name: Isoleucine

Registry Number: 73-32-5

Grant and Affiliation Information for Acyclic stereoselective boron alkylation reactions for the asymmetric synthesis of beta-substituted alpha-amino acid derivatives.

AFFILIATION: Department of Chemistry, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA. odonnell@chem.iupui.edu

Country: United States

AGENCY: United States NIGMS

GRANT: GM 28193

ACRONYM: GM

MEDLINETA: J Am Chem Soc

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