Acute phase proteins do not account for unmeasured anions in critical illness.

Acute phase proteins do not account for unmeasured anions in critical illness. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Acute phase proteins do not account for unmeasured anions in critical illness. Abstract Text:

N Kneidinger,G Lindner,V Fuhrmann,D Doberer,D Dunkler,B Schneeweiss,G C Funk,

BACKGROUND: The increasingly recognized prognostic impact of the strong ion gap in critical illness is in contrast to its largely unknown chemical nature. Experimental and clinical evidence suggest that acute phase proteins might account for elevation of the strong ion gap. The hypothesis of this investigation was that acute phase proteins account for strong ion gap in critically ill patients. MATERIALS AND METHODS: The charges of the two acute phase proteins C-reactive protein and fibrinogen were estimated by a computer model. Additionally, 142 patients admitted to a medical intensive care unit of a university hospital were studied prospectively during a six month period. Serial daily observations were recorded and classified according to the systemic inflammatory state. The acute phase proteins C-reactive protein and fibrinogen were measured and the strong ion gap was calculated from the measured acid-base variables. RESULTS: The approximated mean charges of C-reactive protein and fibrinogen at a pH of 7.4 are -4.0 and -13.6 per molecule, respectively. Therefore, their negative charge is too small to explain the elevated strong ion gap even during a substantial increase of C-reactive protein and fibrinogen due to an acute-phase reaction. Moreover, C-reactive protein did not correlate with the strong ion gap when partialized for creatinine (R = 0.02, P = 0.567). Fibrinogen did not correlate with the strong ion gap. Creatinine correlated with the strong ion gap (R = 0.42, P < 0.001). Neither systemic inflammatory state nor increasing C-reactive protein levels were associated with an increasing strong ion gap. CONCLUSION: Acute phase proteins do not account for an elevated strong ion gap in critically ill patients.

Acute phase proteins do not account for unmeasured anions in critical illness. Publishing Authors By Initials

N Kneidinger,G Lindner,V Fuhrmann,D Doberer,D Dunkler,B Schneeweiss,GC Funk,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Acute phase proteins do not account for unmeasured anions in critical illness. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of clinical investigation

VOLUME: 37

Page Numbers: 820-5

Journal Abbreviation: Eur. J. Clin. Invest.

ISSN: 0014-2972

DAY: 30

MONTH: 08

YEAR: 2007

Acute phase proteins do not account for unmeasured anions in critical illness. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 245331

Acute phase proteins do not account for unmeasured anions in critical illness. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Acute phase proteins do not account for unmeasured anions in critical illness. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Acute phase proteins do not account for unmeasured anions in critical illness.

AFFILIATION: Intensive Care Unit 13H1, Medical University of Vienna, Austria. nikolaus.kneidinger@qmx.at

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Eur J Clin Invest

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Acute phase proteins do not account for unmeasured anions in critical illness Related Publications

• 6-Bromomethyl-4H-1,3-dioxin: a versatile bromomethyl vinyl ketone equivalent for heterocycle and carbocycle construction.
• A comparison of human and near-optimal task management behavior.
• A novel genetic model of selective COX-2 inhibition: comparison with COX-2 null mice.
• A strategy for the total synthesis of dragmacidin E. Construction of the core ring system.
• Acute phase proteins do not account for unmeasured anions in critical illness.
• An approach to the total synthesis of welwistatin.
• Association of small CAB-like proteins (SCPs) of Synechocystis sp. PCC 6803 with Photosystem II.
• Development and validation of the GAIN Short Screener (GSS) for internalizing, externalizing and substance use disorders and crime/violence problems among adolescents and adults.
• Diastereoselective synthesis of 2,3,6-trisubstituted tetrahydropyran-4-ones via Prins cyclizations of enecarbamates: a formal synthesis of (+)-ratjadone A.
• ECG monitoring after cardiac surgery: postoperative atrial fibrillation and the atrial electrogram.
• General health measures and long-term survival in patients with head and neck cancer.
• Generation of N-acyliminium ions via intramolecular conjugate addition reactions: a strategy for the total synthesis of nakadomarin A.
• Generation of aza-ortho-xylylenes via ring opening of 2-(2-acylaminophenyl)aziridines: application in the construction of the communesin ring system.
• Health-related quality of life profiles based on survivorship status for head and neck cancer patients.
• Influence of social support on health-related quality of life outcomes in head and neck cancer.
• Patient-reported factors associated with discontinuing employment following head and neck cancer treatment.
• Powassan Virus: Surveys of Human and Animal Sera.
• Prevalence and comorbidity of major internalizing and externalizing problems among adolescents and adults presenting to substance abuse treatment.
• Response to Protocol Review Scenario: Potential complications.
• SUN WORSHIPPING IN PENNSYLVANIA.
• Scoring System for the Severity of the Metabolic Syndrome: 2161: Board #74 June 1 8:00 AM - 9:30 AM.
• Secondary alkyl hydroperoxides as inhibitors and alternate substrates for lipoxygenase.
• Synthesis of indoles via 6pi-electrocyclic ring closures of trienecarbamates.
• Targeted cyclooxygenase gene (ptgs) exchange reveals discriminant isoform functionality.
• The classification of tumors of bone and the presenting clinical symptoms.
• The interaction of co-occurring mental disorders and recovery management checkups on substance abuse treatment participation and recovery.
• Total syntheses of (+/-)-beta-erythroidine and (+/-)-8-oxo-beta-erythroidine by an intramolecular Diels-Alder cycloaddition of a 2-amidoacrolein.
• Total syntheses of (+/-)-cis-trikentrin A and (+/-)-cis-trikentrin B via electrocyclic ring closures of 2,3-divinylpyrrolines.
• Total synthesis of (+/-)-perophoramidine.
• [Not Available.]