Acute motor axonal neuropathy during intensive immunosuppressive therapy for macrophage activation syndrome.

Acute motor axonal neuropathy during intensive immunosuppressive therapy for macrophage activation syndrome. Research Abstract Details 

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Acute motor axonal neuropathy during intensive immunosuppressive therapy for macrophage activation syndrome. Abstract Text:

Katsunori Fujii,Kasumi Nagasawa,Yuzaburo Inoue,Shuichi Suzuki,Hideki Uchikawa,Yoichi Kohno,

We describe a 2-year-old girl with refractory macrophage activation syndrome (MAS), which is a serious complication of inflammatory disorders associated with rheumatic disease in children. Although she was treated with intensive immunosuppressive therapies such as immunoglobulin, plasma exchange, dexamethasone, methotrexate, cyclosporine, and etoposide, she subsequently developed motor deficit with the abolition of deep tendon reflexes. Since nerve conduction study revealed low-amplitude compound muscle action potentials and motor conduction slowing, she was diagnosed as having acute motor axonal neuropathy (AMAN) associated with refractory MAS. This is the first report of AMAN occurring during immunosuppressive therapy for extremely refractory MAS, suggesting that hypercytokinemia or activated macrophages may have played a critical role in the pathogenesis of AMAN in this patient.

Acute motor axonal neuropathy during intensive immunosuppressive therapy for macrophage activation syndrome. Publishing Authors By Initials

K Fujii,K Nagasawa,Y Inoue,S Suzuki,H Uchikawa,Y Kohno,

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Acute motor axonal neuropathy during intensive immunosuppressive therapy for macrophage activation syndrome. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Brain & development

VOLUME: 30

Page Numbers: 160-3

Journal Abbreviation: Brain Dev.

ISSN: 0387-7604

DAY: 30

MONTH: 07

YEAR: 2007

Acute motor axonal neuropathy during intensive immunosuppressive therapy for macrophage activation syndrome. Information

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LANGUAGE: eng

NlmUniqueID: 7909235

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Grant and Affiliation Information for Acute motor axonal neuropathy during intensive immunosuppressive therapy for macrophage activation syndrome.

AFFILIATION: Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, Japan.

Country: Netherlands

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MEDLINETA: Brain Dev

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