Acute lymphoblastic leukaemia.

Acute lymphoblastic leukaemia. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Acute lymphoblastic leukaemia. Abstract Text:

Ching-Hon Pui,Leslie L Robison,A Thomas Look,Ching-Hon Pui,Leslie L Robison,A Thomas Look,

Acute lymphoblastic leukaemia, a malignant disorder of lymphoid progenitor cells, affects both children and adults, with peak prevalence between the ages of 2 and 5 years. Steady progress in development of effective treatments has led to a cure rate of more than 80% in children, creating opportunities for innovative approaches that would preserve past gains in leukaemia-free survival while reducing the toxic side-effects of current intensive regimens. Advances in our understanding of the pathobiology of acute lymphoblastic leukaemia, fuelled by emerging molecular technologies, suggest that drugs specifically targeting the genetic defects of leukaemic cells could revolutionise management of this disease. Meanwhile, studies are underway to ascertain the precise events that take place in the genesis of acute lymphoblastic leukaemia, to enhance the clinical application of known risk factors and antileukaemic agents, and to identify treatment regimens that might boost the generally low cure rates in adults and subgroups of children with high-risk leukaemia.

Acute lymphoblastic leukaemia. Publishing Authors By Initials

CH Pui,LL Robison,AT Look,CH Pui,LL Robison,AT Look,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Acute lymphoblastic leukaemia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Lancet

VOLUME: 371

Page Numbers: 1030-43

Journal Abbreviation: Lancet

ISSN: 1474-547X

DAY: 22

MONTH: Mar

YEAR: 2008

Acute lymphoblastic leukaemia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985213

Acute lymphoblastic leukaemia. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Acute lymphoblastic leukaemia. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Acute lymphoblastic leukaemia.

AFFILIATION: Department of Oncology, St Jude Children's Research Hospital and University of Tennessee Health Science Center, Memphis, TN 38105, USA. ching-hon.pui@stjude.org

Country: England

AGENCY: United States NINR

GRANT: NR07610

ACRONYM: NR

MEDLINETA: Lancet

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Acute lymphoblastic leukaemia Related Publications

• A creative response meets community need/enriches hospital.
• Activating mutations in ALK provide a therapeutic target in neuroblastoma.
• Acute lymphoblastic leukaemia.
• Chk1 Suppresses a Caspase-2 Apoptotic Response to DNA Damage that Bypasses p53, Bcl-2, and Caspase-3.
• Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation.
• Combined source-detector response characteristics.
• Dominant-interfering C/EBPalpha stimulates primitive erythropoiesis in zebrafish.
• FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors.
• Identification of structural aberrations in cancer by SNP array analysis.
• Inhibition of Jak1-dependent signal transduction in airway epithelial cells infected with adenovirus.
• Mechanisms of transcription factor deregulation in lymphoid cell transformation.
• Myelopoiesis in the zebrafish, Danio rerio.
• NOTCH and PI3K-AKT pathways intertwined.
• Type 2 diabetes in native Hawaiians and Pacific Islanders in Hawaii.