Acute hypoxia differentially affects the gamma-aminobutyric acid type A receptor alpha(1), alpha(2), beta(2), and gamma(2) subunit mRNA levels in the developing chick optic tectum: Stage-dependent sensitivity.

Acute hypoxia differentially affects the gamma-aminobutyric acid type A receptor alpha(1), alpha(2), beta(2), and gamma(2) subunit mRNA levels in the developing chick optic tectum: Stage-dependent sensitivity. Research Abstract Details 

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Acute hypoxia differentially affects the gamma-aminobutyric acid type A receptor alpha(1), alpha(2), beta(2), and gamma(2) subunit mRNA levels in the developing chick optic tectum: Stage-dependent sensitivity. Abstract Text:

Sara Fiszer de Plazas,Melina Rapacioli, Gil,Marina Vacotto,Vladimir Flores,Sara Fiszer de Plazas,Melina Rapacioli, Gil,Marina Vacotto,Vladimir Flores,Sara Fiszer de Plazas,Melina Rapacioli,Diego J Rodríguez Gil,Marina Vacotto,Vladimir Flores,

This investigation analyzes the effect of an acute hypoxic treatment on the level of four (alpha(1), alpha(2), beta(2), and gamma(2)) subunit mRNAs of the GABA(A) receptor in layer "i" of the developing chick optic tectum. Our results show that 1 hr of normobaric acute hypoxia significantly changes the subunit mRNA levels. Different subunit mRNAs display different sensitivity to hypoxia: alpha(1), beta(2), and gamma(2) mRNAs are highly sensitive, whereas alpha(2) mRNA is almost not affected. The sensitivity of the mRNA levels to hypoxia is stage dependent. The mean percentages of variation produced by the hypoxia in the level of expression of the four subunits were 20% at ED12, 5% at ED16, and only 2% at ED18. These changes in the mean percentages of expression modify the probability of coexpression. In the case of double mRNA combinations, the hypoxia produced a mean variation in the probability of coexpression of 37% at ED12, 8% at ED16, and only 4% at ED18. With regard to the triple subunit mRNAs combinations, the variations were 206% at ED12, 11% at ED16, and only 7% at ED18. The quadruple combination values were 1,500% at ED12, 21% at ED16, and only 11% at ED18. This study demonstrates that the subunit mRNA levels are highly sensitive during the early stages, suggesting that GABA(A) receptor composition might undergo environment-dependent plastic changes providing a high degree of plasticity to the GABA neurotransmitter system development. (c) 2007 Wiley-Liss, Inc.

Acute hypoxia differentially affects the gamma-aminobutyric acid type A receptor alpha(1), alpha(2), beta(2), and gamma(2) subunit mRNA levels in the developing chick optic tectum: Stage-dependent sensitivity. Publishing Authors By Initials

SF Plazas,M Rapacioli,DJ Gil,M Vacotto,V Flores,SF de Plazas,M Rapacioli,DJ Gil,M Vacotto,V Flores,SF de Plazas,M Rapacioli,DJ Gil,M Vacotto,V Flores,

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Acute hypoxia differentially affects the gamma-aminobutyric acid type A receptor alpha(1), alpha(2), beta(2), and gamma(2) subunit mRNA levels in the developing chick optic tectum: Stage-dependent sensitivity. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of neuroscience research

VOLUME: 85

Page Numbers: 3135-44

Journal Abbreviation: J. Neurosci. Res.

ISSN: 0360-4012

DAY: 1

MONTH: Nov

YEAR: 2007

Acute hypoxia differentially affects the gamma-aminobutyric acid type A receptor alpha(1), alpha(2), beta(2), and gamma(2) subunit mRNA levels in the developing chick optic tectum: Stage-dependent sensitivity. Information

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LANGUAGE: eng

NlmUniqueID: 7600111

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Grant and Affiliation Information for Acute hypoxia differentially affects the gamma-aminobutyric acid type A receptor alpha(1), alpha(2), beta(2), and gamma(2) subunit mRNA levels in the developing chick optic tectum: Stage-dependent sensitivity.

AFFILIATION: Institute of Cell Biology and Neuroscience Prof. E. De Robertis, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.

Country: United States

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MEDLINETA: J Neurosci Res

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