Acute hypocalcemic effects of clinical contrast media injections.

Acute hypocalcemic effects of clinical contrast media injections. Research Abstract Details 

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Acute hypocalcemic effects of clinical contrast media injections. Abstract Text:

R E Berger,L S Gomez,L E Mallette,

A decrease in free ionic calcium levels has been reported in the coronary sinus after coronary artery injections of small doses (9 ml) of radiographic contrast media, but there were no studies of the systemic effects of larger doses of medium. Therefore, the acute effects of two commonly used radiographic contrast media on calcium metabolism were studied in nine patients undergoing angiography and five patients undergoing computed tomography. Free ionic calcium (Ca++) in serum was measured by ion-specific electrode, and immunoreactive parathyroid hormone by a highly sensitive radioimmunoassay. Infusion of Renografin or Reno-M-DIP acutely lowered serum Ca++ and produced an immediate increase in parathyroid hormone in each patient studied. Serum Ca++ fell to or below the lower limit of normal in about half the patients. The changes in Ca++ and parathyroid hormone were 2.5- to 4.5-fold greater than those observed after rapid infusion of equal or larger volumes of normal saline. In vitro, the contrast media had no direct effect on the parathyroid hormone assay, but reduced the Ca++ concentration of aqueous calcium solutions by about the amount predicted from their content of disodium edetate and sodium citrate. Contrast agents that contain divalent cation chelators should be used with care in patients in whom a fall in free ionic calcium might have detrimental effects.

Acute hypocalcemic effects of clinical contrast media injections. Publishing Authors By Initials

RE Berger,LS Gomez,LE Mallette,

For similar tomography, x-ray computed research abstracts see: tomography, x-ray computed research

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Acute hypocalcemic effects of clinical contrast media injections. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: AJR. American journal of roentgenology

VOLUME: 138

Page Numbers: 283-8

Journal Abbreviation:

ISSN: 0361-803X

DAY: 15

MONTH: Feb

YEAR: 1982

Acute hypocalcemic effects of clinical contrast media injections. Information

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LANGUAGE: eng

NlmUniqueID: 7708173

Acute hypocalcemic effects of clinical contrast media injections. Keywords Mesh Terms:

KEYWORDS: Tomography, X-Ray Computed

MESH TERMS: adverse effects

Chemical & Substance for Abstract: Acute hypocalcemic effects of clinical contrast media injections. Information

Substance Name: Calcium

Registry Number: 7440-70-2

Grant and Affiliation Information for Acute hypocalcemic effects of clinical contrast media injections.

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Country: UNITED STATES

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MEDLINETA: AJR Am J Roentgenol

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