Acute exposure of uranyl nitrate causes lipid peroxidation and histopathological damage in brain and bone of wistar rat.

Acute exposure of uranyl nitrate causes lipid peroxidation and histopathological damage in brain and bone of wistar rat. Research Abstract Details 

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Acute exposure of uranyl nitrate causes lipid peroxidation and histopathological damage in brain and bone of wistar rat. Abstract Text:

Somnath Ghosh,Amit Kumar,Badri Narain Pandey,Kaushala Prasad Mishra,Somnath Ghosh,Amit Kumar,Badri Narain Pandey,Kaushala Prasad Mishra,

Although the kidneys are the main target organs for uranium (U) toxicity, recent studies have shown that U can cross the blood-brain barrier to accumulate in the brain. Uranyl nitrate (U-238)induced oxidative damage was investigated in brain and bone of Wistar rats after intraperitoneal injection of uranyl nitrate at acute doses either nephrotoxic (576 mug of U/kg body weight) or subnephrotoxic (144 mug U/kg body weight). The health effects of U administration at 576 mug of U/kg body weight were seen in terms of decrease in food intake and no gain in body weight compared to respective controls. These alterations were correlated with increased lipid peroxidation as measured by thiobarbituric acid reactive substances in rat brain and bone. However, at lower dosage of U (144 mug U/kg body weight), no significant lipid peroxidation was observed in brain and bone. Histological examination of U-treated (576 mug of U/kg body weight) rat brain tissues showed marked and diffuse cystic degeneration and a similar pattern in histological alterations was observed in kidneys in treated animals; whereas no significant histological change was observed in rat brains and kidney treated with a lower dose of U (144 mug U/kg body weight). It is concluded that administration of U at an acute nephrotoxic dose caused oxidative stress in brain and bone manifested as lipid peroxidation and histopathological damage.

Acute exposure of uranyl nitrate causes lipid peroxidation and histopathological damage in brain and bone of wistar rat. Publishing Authors By Initials

S Ghosh,A Kumar,BN Pandey,KP Mishra,S Ghosh,A Kumar,BN Pandey,KP Mishra,

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Acute exposure of uranyl nitrate causes lipid peroxidation and histopathological damage in brain and bone of wistar rat. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of environmental pathology, toxicology and

VOLUME: 26

Page Numbers: 255-61

Journal Abbreviation: J. Environ. Pathol. Toxicol. O

ISSN: 0731-8898

DAY: 16

MONTH: 01

YEAR: 2007

Acute exposure of uranyl nitrate causes lipid peroxidation and histopathological damage in brain and bone of wistar rat. Information

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LANGUAGE: eng

NlmUniqueID: 8501420

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AFFILIATION: Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai-400 085, India.

Country: United States

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MEDLINETA: J Environ Pathol Toxicol Oncol

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