Acute effect of vasectomy on the function of the rat epididymal epithelium and vas deferens.

Acute effect of vasectomy on the function of the rat epididymal epithelium and vas deferens. Research Abstract Details 

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Acute effect of vasectomy on the function of the rat epididymal epithelium and vas deferens. Abstract Text:

Ann E Lavers,David J Swanlund,Brian A Hunter,Michael L Tran,Jon L Pryor,Kenneth P Roberts,

Persistent infertility after apparently successful vasectomy reversal is common. One possible etiology is epididymal epithelial dysfunction resulting in improper sperm maturation after vasectomy reversal. The epididymal epithelium secretes a number of proteins that are thought to be required for the maturation of sperm. Ligation of the vas deferens during vasectomy may affect the synthesis of some of these proteins. In the present study, the function of the epididymal epithelium was assessed at early times after vasectomy (1, 4, and 7 days) by measuring the level of mRNA of 4 secreted proteins: Crisp-1, clusterin, osteopontin, and transferrin. In addition, the site of synthesis of these proteins was determined by immunocytochemistry. The results demonstrated that the expression of Crisp-1 and clusterin, representative epididymal secretory proteins, was largely unaffected by vasectomy. However, osteopontin mRNA increased in the vas deferens in response to vasectomy. Immunocytochemical localization of osteopontin suggested that both infiltrating immune cells and deferential luminal epithelium were responsible for this up-regulation. Transferrin expression was viewed as a marker for immune cells at the site of injury. However, both the caput epididymis and deferential epithelia were found to express transferrin, in addition to immune cells. In conclusion, there appear to be only minor changes in expression of genes encoding epididymal secretory proteins acutely after vasectomy, but, not surprisingly, there was evidence of an inflammatory response after vasectomy.

Acute effect of vasectomy on the function of the rat epididymal epithelium and vas deferens. Publishing Authors By Initials

AE Lavers,DJ Swanlund,BA Hunter,ML Tran,JL Pryor,KP Roberts,

For similar vasectomy research abstracts see: vasectomy research

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Acute effect of vasectomy on the function of the rat epididymal epithelium and vas deferens. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of andrology

VOLUME: 27

Page Numbers: 826-36

Journal Abbreviation: J. Androl.

ISSN: 0196-3635

DAY: 12

MONTH: 07

YEAR: 2006

Acute effect of vasectomy on the function of the rat epididymal epithelium and vas deferens. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8106453

Acute effect of vasectomy on the function of the rat epididymal epithelium and vas deferens. Keywords Mesh Terms:

KEYWORDS: Vasectomy

MESH TERMS: physiology

Chemical & Substance for Abstract: Acute effect of vasectomy on the function of the rat epididymal epithelium and vas deferens. Information

Substance Name: Transferrin

Registry Number: 11096-37-0

Grant and Affiliation Information for Acute effect of vasectomy on the function of the rat epididymal epithelium and vas deferens.

AFFILIATION: Department of Urologic Surgery, University of Minnesota Medical School, Minneapolis, MN 55455, USA.

Country: United States

AGENCY: United States NICHD

GRANT: HD00997

ACRONYM: HD

MEDLINETA: J Androl

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