Acute depletion of plasma glutamine increases leucine oxidation in prednisone-treated humans.

Acute depletion of plasma glutamine increases leucine oxidation in prednisone-treated humans. Research Abstract Details 

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Acute depletion of plasma glutamine increases leucine oxidation in prednisone-treated humans. Abstract Text:

Olivier Le Bacquer,Nelly Mauras,Susan Welch,Morey Haymond,Dominique Darmaun,Olivier Le Bacquer,Nelly Mauras,Susan Welch,Morey Haymond,Dominique Darmaun,

BACKGROUND, AIMS & METHODS: To determine whether depletion in plasma glutamine worsens the catabolic response to corticosteroids, seven healthy volunteers received oral prednisone for 6 days on two separate occasions, at least 2 weeks apart, and in random order. On the sixth day of each treatment course, they received 5 h intravenous infusions of L-[1-(14)C]-leucine and L-[1-(13)C]-glutamine in the postabsorptive state (1) under baseline conditions (prednisone only day) and (2) after 24h of treatment with phenylbutyrate (prednisone+phenylbutyrate day), a glutamine chelating agent. RESULTS: Phenylbutyrate treatment was associated with (1) an approximately 15% decline in plasma glutamine concentration (627+/-39 vs. 530+/-31 micromol l(-1); P<0.05), (2) no change in leucine appearance rate, an index of protein breakdown (124+/-9 vs. 128+/-9 micromol kg(-1) h(-1); NS) nor in non-oxidative leucine disposal, an index of whole body protein synthesis (94+/-9 vs. 91+/-7 micromol kg(-1) h(-1); NS), and (3) a approximately 25% rise in leucine oxidation (30+/-1 vs. 38+/-2 micromol kg(-1) h(-1), P<0.05), despite an approximately 25% decline (P<0.05) in leucine concentration. CONCLUSIONS: In a model of mild, stress-induced protein catabolism, depletion of plasma glutamine per se may worsen branched chain amino acid and protein wasting.

Acute depletion of plasma glutamine increases leucine oxidation in prednisone-treated humans. Publishing Authors By Initials

O Le Bacquer,N Mauras,S Welch,M Haymond,D Darmaun,O Le Bacquer,N Mauras,S Welch,M Haymond,D Darmaun,

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Acute depletion of plasma glutamine increases leucine oxidation in prednisone-treated humans. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical nutrition (Edinburgh, Scotland)

VOLUME: 26

Page Numbers: 231-8

Journal Abbreviation:

ISSN: 0261-5614

DAY: 13

MONTH: 11

YEAR: 2006

Acute depletion of plasma glutamine increases leucine oxidation in prednisone-treated humans. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8309603

Acute depletion of plasma glutamine increases leucine oxidation in prednisone-treated humans. Keywords Mesh Terms:

KEYWORDS: Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Acute depletion of plasma glutamine increases leucine oxidation in prednisone-treated humans. Information

Substance Name: Leucine

Registry Number: 61-90-5

Grant and Affiliation Information for Acute depletion of plasma glutamine increases leucine oxidation in prednisone-treated humans.

AFFILIATION: INSERM U.539, Centre de Recherche en Nutrition Humaine, Nantes, France.

Country: England

AGENCY: United States NIDDK

GRANT: R01 DK-51477

ACRONYM: DK

MEDLINETA: Clin Nutr

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